1,8-Diazafluoren-9-one
- CAS No.54078-29-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 1,8-Diazafluoren-9-one (CAS 54078-29-4) is a critical intermediate for peptide coupling reagents and organometallic catalysis.
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Product Overview
1,8-Diazafluoren-9-one represents a critical heterocyclic compound widely utilized in advanced organic synthesis and pharmaceutical manufacturing sectors. This high-performance intermediate serves as a foundational building block for the production of potent peptide coupling reagents, including but not limited to HATU and related uronium salts. Our facility ensures consistent supply chains for research laboratories and industrial scale operations requiring exceptional chemical stability and purity. The molecular structure features a unique diazafluorene backbone, providing superior reactivity profiles compared to traditional fluorene derivatives. This characteristic makes it indispensable for modern medicinal chemistry programs focused on developing novel therapeutic agents. We maintain rigorous production standards to meet the demanding specifications of global pharmaceutical clients seeking reliable raw materials.
The significance of this chemical entity extends beyond simple intermediacy. It plays a pivotal role in optimizing reaction kinetics during amide bond formation, which is a cornerstone process in peptide drug development. By utilizing our premium grade material, chemists can achieve higher yields and reduced impurity profiles in their final active pharmaceutical ingredients. Our commitment to quality ensures that every batch supports the integrity of your downstream synthesis processes.
Technical Specifications
| Items Of Analysis | Standard Of Analysis | Test Results |
|---|---|---|
| Appearance | Off-white To Yellow Crystal Powder | Conforms |
| Loss On Drying | ≤0.5% | 0.22% |
| Assay | ≥99.0% | 99.16% |
| Conclusion | Conforms To Factory Standard | |
Our analytical department employs state-of-the-art instrumentation including High Performance Liquid Chromatography and Nuclear Magnetic Resonance spectroscopy to verify all parameters listed above. The melting point range of 229 to 233 degrees Celsius indicates high crystalline integrity. Density and boiling point data further confirm the identity and purity of the substance. We provide comprehensive documentation with every shipment to facilitate regulatory compliance and quality control audits within your organization.
Industrial Applications
The versatility of this compound extends across multiple sectors within the fine chemicals industry. Primary usage scenarios involve the synthesis of activation agents for amide bond formation, a crucial step in peptide drug development. Additionally, it functions as a ligand in organometallic catalysis, enhancing reaction efficiency in polymerization processes. Researchers value this material for its stability under various reaction conditions and its compatibility with diverse solvent systems.
- Peptide Coupling Reagent Precursor
- Organometallic Catalyst Ligand
- Organic Synthesis Building Block
- Pharmaceutical Intermediate Manufacturing
Quality Assurance And Storage
Every batch undergoes comprehensive analytical testing to verify compliance with established factory standards. Parameters such as assay purity, loss on drying, and physical appearance are meticulously documented in the Certificate Of Analysis. Proper storage conditions are essential to maintain product integrity over extended periods. We recommend maintaining inventory in a cool, dry environment between two to eight degrees Celsius. Protection from strong oxidizing agents is necessary to prevent degradation. Our logistics team ensures secure packaging for global shipment, guaranteeing that materials arrive in optimal condition for immediate use in your production workflows. Contact our technical support team for detailed safety data sheets and handling guidelines.
