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1-Benzo[b]thien-4-ylpiperazine Monohydrochloride
- CAS No.913614-18-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Benzo[b]thien-4-ylpiperazine monohydrochloride (CAS 913614-18-3), a key pharmaceutical intermediate for advanced CNS drug synthesis.
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Product Overview
1-Benzo[b]thien-4-ylpiperazine monohydrochloride is a high-value heterocyclic building block widely employed in the synthesis of complex pharmaceutical active pharmaceutical ingredients (APIs). With a defined molecular formula of C12H15ClN2S and a molecular weight of 254.78 g/mol, this compound serves as a critical intermediate in the development of next-generation neurological therapeutics, particularly in routes leading to brexpiprazole-related scaffolds.
Specifications
| Appearance | White powder |
|---|---|
| Purity (HPLC) | ≥99.0% |
| Loss on Drying | ≤0.5% |
| Water Content (KF) | ≤1.0% |
| Heavy Metals | ≤10 ppm |
| Inorganic Salts | ≤0.1% |
| Non-Specific Impurity | ≤0.10% |
| Total Impurities | ≤0.50% |
Industrial Applications
This piperazine derivative is primarily utilized as a specialized intermediate in multi-step organic syntheses within the pharmaceutical industry. Its rigid benzo[b]thiophene core coupled with a functionalized piperazine moiety enables efficient construction of target molecules with enhanced receptor-binding profiles. Key application areas include:
- Synthesis of serotonin-dopamine activity modulators (SDAMs) for central nervous system (CNS) drug discovery
- Building block for novel antipsychotic and anxiolytic candidate molecules
- Intermediate in GMP-compliant API manufacturing processes requiring stringent impurity control
Stored in a cool, dry, and tightly sealed container away from moisture, heat, and direct light, the product maintains stability under recommended conditions. Standard packaging is 25 kg in fiber drums, with custom options available for industrial-scale procurement.
