Intermediates

1-Boc-2-[4-(2-Pyridinyl)benzylidene]hydrazine

  • CAS No.198904-85-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1-Boc-2-[4-(2-pyridinyl)benzylidene]hydrazine (CAS 198904-85-7), a critical intermediate for advanced antiviral and proteasome inhibitor APIs.

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Product Technical Details

Product Overview

1-Boc-2-[4-(2-Pyridinyl)benzylidene]hydrazine is a high-value, protected hydrazine derivative widely employed as a key building block in the synthesis of complex pharmaceutical active ingredients. With a molecular formula of C17H21N3O2 and a molecular weight of 299.37 g/mol, this compound features a tert-butoxycarbonyl (Boc) protecting group and a conjugated pyridinylbenzylidene moiety, offering excellent reactivity control and stability during multi-step organic syntheses.

Specifications

Molecular FormulaC17H21N3O2
Molecular Weight299.37 g/mol
Density1.17 g/cm³
Melting Point74–77 °C
Refractive Index1.555
AppearanceOff-white to white powder
Purity (HPLC)≥99%
Water Content (KF)≤0.5%

Industrial Applications

This compound serves as a strategic intermediate in the manufacture of several high-profile therapeutic agents. It is specifically utilized in synthetic routes toward advanced antiviral and oncology APIs, including those structurally related to protease and proteasome inhibitors. Its robust chemical architecture enables precise functionalization in late-stage transformations, making it indispensable in modern medicinal chemistry campaigns.

  • Enables efficient construction of nitrogen-containing heterocyclic scaffolds
  • Compatible with standard deprotection and coupling protocols in solid- and solution-phase synthesis
  • Supplied under strict GMP-aligned quality control for reproducible batch performance

Handling and Storage

Store in a tightly sealed container in a cool, dry place away from direct sunlight, heat sources, and moisture. For industrial use only—handle in accordance with local regulatory guidelines for fine chemical intermediates.