1-Boc-3-piperidone
- CAS No.98977-36-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Boc-3-piperidone (CAS 98977-36-7) is a essential protected piperidone building block for pharmaceutical synthesis, available with full COA.
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Product Overview
1-Boc-3-piperidone, chemically known as tert-butyl 3-oxopiperidine-1-carboxylate, stands as a pivotal nitrogen-containing heterocyclic building block in modern medicinal chemistry. This compound features a piperidine ring protected by a tert-butoxycarbonyl (Boc) group at the nitrogen position, with a ketone functionality at the third position. This specific structural arrangement provides chemists with a versatile scaffold for constructing complex molecular architectures required in the development of advanced therapeutic agents.
Our manufacturing facility specializes in the production of high-grade chemical intermediates, ensuring that every batch of 1-Boc-3-piperidone meets stringent quality criteria. The Boc protection group is particularly valued in multi-step organic synthesis due to its stability under various reaction conditions and its ease of removal under acidic conditions. This makes the compound an ideal candidate for use in the synthesis of kinase inhibitors, central nervous system agents, and other specialized pharmaceutical active ingredients.
Technical Specifications
We adhere to rigorous quality control protocols to guarantee consistency and reliability for our global partners. The following table outlines the key physical and chemical parameters verified through our internal laboratory testing procedures.
| Parameter | Specification | Typical Result |
|---|---|---|
| Appearance | Off-white to light yellow solid | Off-white solid |
| CAS Number | 98977-36-7 | Conforms |
| Molecular Formula | C10H17NO3 | Conforms |
| Molecular Weight | 199.25 g/mol | Conforms |
| Purity (GC) | ≥99.0% | 99.7% |
| Impurity (3-Piperidinone) | ≤0.01% | Conforms |
| Impurity (TEMPO) | ≤0.05% | Conforms |
| Storage Temperature | 0-5°C | Controlled |
Industrial Applications
As a key intermediate, 1-Boc-3-piperidone finds extensive application in the research and development sectors of the pharmaceutical industry. The ketone group at the 3-position allows for various chemical transformations, including reductive amination, Grignard additions, and Wittig reactions. These transformations enable the introduction of diverse side chains, facilitating the optimization of biological activity during drug discovery phases.
Furthermore, the stability of the Boc group ensures that the nitrogen atom remains protected during reactions targeting other functional groups within the molecule. This orthogonal protection strategy is crucial for the efficient synthesis of complex heterocycles found in modern medications. Our clients utilize this material for scale-up production processes, where consistent purity and low levels of specific impurities like free piperidinone are critical for downstream reaction success.
Quality Assurance and Storage
Quality is the cornerstone of our operation. Each production lot undergoes comprehensive analysis using gas chromatography and other validated methods to confirm identity and purity. We provide a Certificate of Analysis (COA) with every shipment, detailing the specific test results for your quality assurance records. To maintain the integrity of the product, proper storage conditions are essential.
It is recommended to store 1-Boc-3-piperidone in a cool, dry environment, specifically between 0 to 5 degrees Celsius. Protection from moisture and light is advised to prevent potential degradation of the Boc group or oxidation of the ketone functionality. Our packaging solutions are designed to ensure stability during international transit, supporting our commitment to being a reliable global manufacturer for your synthesis needs.
