1-Bromo-2,3,4,5,6-pentafluorobenzene
- CAS No.344-04-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Bromo-2,3,4,5,6-pentafluorobenzene (CAS 344-04-7) for advanced organic synthesis. Available in bulk with COA.
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Product Overview
1-Bromo-2,3,4,5,6-pentafluorobenzene is a highly specialized halogenated aromatic compound that serves as a critical building block in modern chemical synthesis. Characterized by a benzene ring where five hydrogen atoms are substituted with fluorine and one with bromine, this molecule offers unique reactivity profiles essential for developing advanced materials and pharmaceutical intermediates. Our facility produces this compound under strict quality control standards to ensure consistent performance in downstream applications.
The strategic placement of fluorine atoms enhances metabolic stability and lipophilicity, making derivatives of this compound particularly valuable in medicinal chemistry. As a leading global manufacturer, we provide this reagent with guaranteed purity levels suitable for sensitive catalytic processes and complex organic transformations.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 344-04-7 |
| Molecular Formula | C6BrF5 |
| Molecular Weight | 245.91 g/mol |
| Appearance | Colorless transparent liquid |
| Assay (GC) | ≥99.5% |
| Density | 1.981 g/cm3 |
| Boiling Point | 137oC |
| Melting Point | -31oC |
| Refractive Index | 1.449 |
| Moisture Content | ≤200ppm |
| Single Impurity | ≤0.2% |
| pH Value | 6.0-7.0 |
Synthesis And Production
Our manufacturing process utilizes a refined synthetic route starting from pentafluorobenzoic acid as the primary raw material. Through a controlled decarboxylation sequence, pentafluorobenzene is generated followed by a precise bromination reaction. This method ensures high regioselectivity and minimizes the formation of poly-brominated byproducts. The final product undergoes rigorous distillation and purification steps to achieve the specified industrial purity levels required for high-end research and production environments.
Industrial Applications
This fluorinated aryl bromide is extensively used across multiple sectors due to its versatile coupling capabilities. Key applications include:
- Pharmaceutical Intermediates: Serving as a precursor for synthesizing bioactive molecules where fluorine substitution improves drug efficacy.
- Agrochemical Development: Utilized in the creation of novel pesticides and herbicides with enhanced environmental stability.
- Material Science: Employed in the production of specialized polymers and liquid crystals requiring specific electronic properties.
- Cross-Coupling Reactions: Ideal substrate for palladium-catalyzed reactions such as Suzuki or Heck couplings in organic synthesis.
Quality Assurance And Safety
Every batch of 1-Bromo-2,3,4,5,6-pentafluorobenzene is accompanied by a comprehensive Certificate of Analysis (COA). Our quality control laboratory employs gas chromatography and other analytical techniques to verify assay purity and impurity profiles. We adhere to international safety standards for handling halogenated compounds. Proper storage in a cool, dry place away from oxidizing agents is recommended to maintain product integrity during transportation and warehousing.
