1-Bromo-2,4-Difluorobenzene

Product Overview

1-Bromo-2,4-Difluorobenzene is a highly valued fluorinated aromatic compound widely utilized in the fine chemical and pharmaceutical industries. As a critical building block, this substance serves as a foundational element for constructing complex molecular structures required in modern medicinal chemistry. The presence of both bromine and fluorine substituents on the benzene ring provides unique reactivity profiles, enabling selective nucleophilic aromatic substitution and cross-coupling reactions. Our facility ensures that every batch meets rigorous international standards for purity and consistency, supporting large-scale industrial synthesis as well as specialized research and development projects.

Key Chemical Properties

This compound exists as a liquid at standard ambient temperatures, characterized by its distinct physical constants which facilitate precise handling and processing. The density of approximately 1.708 g/mL indicates a heavy liquid phase, requiring careful measurement during formulation. With a boiling point ranging between 145 to 146 degrees Celsius, it can be distilled under standard or reduced pressure conditions for further purification if necessary. The melting point of minus 4 degrees Celsius ensures stability during storage in cool environments without solidification issues. These physical parameters are critical for process engineers designing reaction vessels and storage systems.

Quality Specifications

We maintain strict quality control protocols to guarantee the performance of 1-Bromo-2,4-Difluorobenzene in downstream applications. The following table outlines the standard specification parameters for our commercial grade product:

Industrial Applications

The primary application of this fluorinated intermediate lies in the synthesis of pharmaceutical active ingredients. It is frequently employed in the development of neurological therapeutics and other complex organic molecules where fluorine substitution enhances metabolic stability and bioavailability. Beyond pharmaceuticals, it serves as a versatile reagent in agrochemical production and material science research. Chemists value this building block for its ability to undergo palladium-catalyzed coupling reactions, making it indispensable for creating biaryl structures. Our global supply chain supports diverse sectors requiring reliable access to high-quality halogenated aromatics.

Storage and Handling

Proper storage is essential to maintain the integrity of 1-Bromo-2,4-Difluorobenzene. The product should be kept in tightly closed containers to prevent moisture absorption and contamination. Recommended storage conditions involve maintaining temperatures between 2 to 8 degrees Celsius in a cool, dry, and well-ventilated area. It is crucial to store this chemical away from incompatible substances such as strong oxidizing agents. Standard packing is available in 25kg drums, ensuring safe transport and handling according to international hazardous material regulations. We provide comprehensive documentation including Certificates of Analysis for every shipment to ensure compliance with your quality assurance systems.