Intermediates

1-Bromo-2-Chloro-3-Fluoro-4-Iodobenzene

  • CAS No.1000573-03-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1-Bromo-2-Chloro-3-Fluoro-4-Iodobenzene (CAS 1000573-03-4) designed for advanced organic synthesis. Reliable supply with ≥97.0% assay for pharmaceutical and chemical manufacturing.

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Product Technical Details

Product Overview

1-Bromo-2-Chloro-3-Fluoro-4-Iodobenzene is a highly specialized polyhalogenated aromatic compound designed for use in complex organic synthesis pathways. As a critical building block, this molecule features a unique arrangement of four different halogen atoms on a benzene ring, providing distinct reactivity profiles that enable selective functionalization. Our manufacturing process ensures consistent quality and high purity, making it an ideal choice for research and industrial applications requiring precise chemical transformations.

The strategic positioning of bromine, chlorine, fluorine, and iodine substituents allows chemists to exploit differences in bond strengths and leaving group abilities. This versatility supports a wide range of cross-coupling reactions, including Suzuki, Heck, and Sonogashira couplings. By utilizing this intermediate, developers can streamline synthetic routes for pharmaceuticals, agrochemicals, and advanced materials.

Key Specifications

We adhere to strict quality control standards to guarantee the performance of every batch. The following table outlines the primary physical and chemical properties verified during our inspection process.

ParameterValue
CAS Number1000573-03-4
Molecular FormulaC6H2BrClFI
Molecular Weight335.340 g/mol
AppearanceYellow to light yellow transparent liquid
Assay (Purity)≥97.0%
Density2.3±0.1 g/cm3
Boiling Point285.7±35.0 °C at 760 mmHg
Flash Point126.6±25.9 °C
Refractive Index1.639

Industrial Applications

This compound serves as a vital intermediate in the production of high-value chemical entities. In the pharmaceutical sector, it is utilized to construct complex molecular scaffolds required for novel drug candidates. The presence of multiple halogens facilitates sequential substitution reactions, allowing for the precise assembly of active pharmaceutical ingredients (APIs).

In agrochemical development, the stability provided by the fluorine and chlorine atoms enhances the environmental persistence and biological activity of final products. Additionally, material science researchers employ this benzene derivative to create specialized polymers and liquid crystals with unique electronic or optical properties. Its compatibility with various catalytic systems makes it a preferred choice for process chemistry teams aiming to optimize yield and efficiency.

Quality Assurance and Storage

Every shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing batch-specific test results. Our quality assurance team conducts rigorous testing using advanced chromatographic and spectroscopic methods to confirm identity and purity. We recommend storing this product in a cool, ventilated area away from direct sunlight and incompatible materials. Proper handling ensures the stability of the chemical properties over extended periods.

We offer flexible packaging options, including standard 25 kg drums, with customization available to meet specific logistical requirements. Our global distribution network ensures timely delivery to support your production schedules. For technical inquiries or custom synthesis requests, our expert support team is available to assist with formulation guidance and scale-up strategies.