Intermediates

1-Bromo-2-fluoro-3-nitrobenzene

  • CAS No.58534-94-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1-Bromo-2-fluoro-3-nitrobenzene (CAS 58534-94-4) designed for advanced pharmaceutical synthesis. Reliable supply with strict quality control for global research needs.

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Product Technical Details

Product Overview

1-Bromo-2-fluoro-3-nitrobenzene is a specialized fluorinated aromatic compound serving as a critical building block in modern organic synthesis. As a key pharmaceutical intermediate, this chemical facilitates the construction of complex molecular architectures required in medicinal chemistry and agrochemical development. Our facility ensures consistent production quality, adhering to rigorous international standards for chemical intermediates used in research and industrial applications.

The presence of both bromine and fluorine substituents on the nitrobenzene ring provides unique reactivity profiles, enabling diverse transformation pathways such as nucleophilic aromatic substitution and cross-coupling reactions. This versatility makes it an invaluable asset for chemists designing new therapeutic agents or functional materials.

Technical Specifications

We maintain strict quality control protocols to guarantee the integrity of every batch. The following table outlines the standard physical and chemical properties associated with this product grade.

ParameterValue
Chemical Name1-Bromo-2-fluoro-3-nitrobenzene
CAS Number58534-94-4
Molecular FormulaC6H3BrFNO2
Molecular Weight219.996 g/mol
Purity≥98.0%
AppearanceWhite solid
Melting Point29-31°C
Boiling Point259.1°C at 760mmHg
Density1.808 g/cm3
Flash Point110.5°C
Refractive Index1.579

Industrial Applications

This compound is primarily utilized in the synthesis of advanced pharmaceutical intermediates. The fluorine atom enhances metabolic stability and bioavailability in drug candidates, while the bromine moiety offers a handle for palladium-catalyzed coupling reactions. Common use cases include the development of kinase inhibitors, receptor modulators, and other small molecule therapeutics.

Beyond pharmaceuticals, this chemical finds application in the creation of specialized polymers and agrochemical agents. Researchers value its stability and predictable reactivity when constructing multi-step synthesis routes. Our supply chain supports both laboratory-scale research and pilot plant operations requiring consistent material properties.

Quality Assurance and Handling

Every shipment is accompanied by a Certificate of Analysis (COA) verifying purity and physical constants. We employ advanced analytical techniques, including HPLC and NMR, to confirm structural integrity. Packaging is designed to maintain stability during transit, typically supplied in 25kg drums sealed against moisture and light.

For safe handling, store this material in a tightly closed container within a cool, dry, and well-ventilated area. Keep away from incompatible substances such as strong oxidizing agents. Proper personal protective equipment should be worn during handling to ensure safety in accordance with standard laboratory protocols. Our team is available to provide technical support and documentation for regulatory compliance.