Intermediates

1-Bromo-3-(difluoromethoxy)benzene

  • CAS No.262587-05-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1-Bromo-3-(difluoromethoxy)benzene (CAS 262587-05-3) is a crucial fluorinated building block designed for advanced organic synthesis and pharmaceutical intermediate manufacturing.

Request Bulk Pricing

Product Technical Details

Product Overview

1-Bromo-3-(difluoromethoxy)benzene is a specialized fluorinated aromatic compound designed for use as a critical building block in modern organic synthesis. As a key intermediate, this substance features a unique structural combination of a bromine substituent and a difluoromethoxy group on the benzene ring. This specific configuration enables versatile chemical transformations, making it highly valuable for research and development within the pharmaceutical and agrochemical sectors. The introduction of fluorine atoms into organic molecules is a strategic approach in medicinal chemistry to enhance metabolic stability and bioavailability. Our manufacturing process ensures consistent quality and high purity levels to meet the rigorous demands of complex synthetic routes required by innovative life science companies.

Chemical Properties and Specifications

The physical and chemical characteristics of this compound are optimized for stability and reactivity in various reaction conditions. The presence of the difluoromethoxy moiety enhances metabolic stability and lipophilicity in downstream molecules, which is a desirable trait in medicinal chemistry. We adhere to strict quality control protocols to guarantee that every batch meets the specified analytical standards. Advanced spectroscopic methods are employed to verify structural integrity. Below are the detailed technical specifications for our standard grade material.

ParameterValue
CAS Number262587-05-3
Molecular FormulaC7H5BrF2O
Molecular Weight223.015 g/mol
AppearanceColorless transparent liquid
Assay (Purity)≥98.0%
Boiling Point197.2±30.0 °C at 760 mmHg
Density1.6±0.1 g/cm3
Flash Point87.0±8.8 °C

Industrial Applications

This fluorinated intermediate serves as an essential precursor in the synthesis of advanced organic compounds. The bromine atom allows for palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings, facilitating the construction of complex biaryl structures. Meanwhile, the difluoromethoxy group is increasingly recognized in drug design for its ability to modulate electronic properties and improve pharmacokinetic profiles. Consequently, this product is widely utilized in the preparation of novel pharmaceutical candidates, agricultural chemicals, and functional materials. It is an ideal choice for chemists seeking reliable starting materials for multi-step synthesis pathways. The versatility of this molecule allows it to be integrated into diverse chemical libraries for high-throughput screening processes.

Quality Assurance and Service

We are committed to providing superior products backed by comprehensive documentation. Each shipment is accompanied by a Certificate of Analysis (COA) to verify identity and purity. Our facility operates under stringent safety and environmental guidelines to ensure sustainable production. We offer flexible packaging options to suit both laboratory-scale research and large-scale industrial manufacturing needs. Our logistics team ensures safe and timely delivery globally, maintaining the integrity of the chemical throughout transit. Customer satisfaction is our priority, and we provide ongoing technical support to assist with integration into your specific processes.

  • High purity standards suitable for sensitive reactions
  • Stable supply chain for continuous production
  • Technical support available for application guidance
  • Custom packaging solutions upon request

Storage and Handling

To maintain optimal quality, store this product in a cool, ventilated place away from direct sunlight and moisture. Keep containers tightly closed when not in use. Standard safety precautions for handling organic bromides and fluorinated compounds should be observed during transfer and processing. Please refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency measures. Proper storage ensures the longevity and performance of the chemical in your manufacturing operations.