1-Bromo-3-Fluoro-2-Nitrobenzene
- CAS No.886762-70-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
Premium grade organic synthesis intermediate with high purity assurance. Ideal for fluorinated compound manufacturing processes.
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Product Overview
1-Bromo-3-Fluoro-2-Nitrobenzene is a highly specialized fluorinated aromatic compound designed for advanced organic synthesis applications. As a critical building block in the pharmaceutical and agrochemical industries, this substance offers exceptional reactivity due to the strategic positioning of bromine, fluorine, and nitro functional groups on the benzene ring. Our manufacturing process ensures consistent quality and high purity levels, making it a reliable choice for complex chemical transformations.
The presence of the fluorine atom enhances the metabolic stability and lipophilicity of downstream products, which is a key requirement in modern medicinal chemistry. Meanwhile, the bromine substituent serves as an excellent handle for cross-coupling reactions, such as Suzuki or Heck couplings. This dual functionality allows chemists to construct sophisticated molecular architectures with precision.
Technical Specifications
We adhere to strict quality control protocols to guarantee that every batch meets rigorous industry standards. The following table outlines the key physical and chemical properties verified during our quality assurance process.
| Parameter | Value |
|---|---|
| CAS Number | 886762-70-5 |
| Molecular Formula | C6H3BrFNO2 |
| Molecular Weight | 219.996 g/mol |
| Appearance | Off-white to light yellow solid |
| Assay (Purity) | ≥98.0% |
| Melting Point | 36-37°C |
| Boiling Point | 232.0±20.0 °C at 760 mmHg |
| Density | 1.8±0.1 g/cm3 |
| Flash Point | 94.1±21.8 °C |
| Refractive Index | 1.580 |
Industrial Applications
This compound is primarily utilized as an intermediate in the synthesis of various fine chemicals. Its unique substitution pattern makes it particularly valuable for developing new active pharmaceutical ingredients (APIs) and crop protection agents. Researchers leverage its properties to introduce fluorine motifs into lead compounds, thereby optimizing pharmacokinetic profiles.
- Used in the preparation of fluorinated heterocycles.
- Serves as a precursor for novel kinase inhibitors.
- Employed in the synthesis of advanced agrochemical formulations.
- Facilitates nucleophilic aromatic substitution reactions.
Safety and Handling
Proper handling procedures are essential when working with nitrobenzene derivatives. Personnel should wear appropriate personal protective equipment, including chemical-resistant gloves and safety goggles. The material should be manipulated in a well-ventilated environment or under a fume hood to minimize exposure to vapors. In case of contact with skin or eyes, immediate flushing with water is recommended.
Packaging and Storage
To maintain stability and integrity, 1-Bromo-3-Fluoro-2-Nitrobenzene is packaged in secure 25 kg drums. Custom packaging solutions are available upon request to meet specific logistical requirements. The product should be stored in a cool, dry, and ventilated area away from direct sunlight and incompatible materials. We provide comprehensive documentation, including Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS), with every shipment to ensure compliance with global safety regulations.
