1-Bromo-3-fluoro-4-iodobenzene
- CAS No.105931-73-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Bromo-3-fluoro-4-iodobenzene (CAS 105931-73-5) is a versatile halogenated aromatic intermediate widely used in cross-coupling reactions for pharmaceutical and agrochemical synthesis.
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Product Overview
1-Bromo-3-fluoro-4-iodobenzene (CAS 105931-73-5) is a multifunctional aryl halide featuring bromo, fluoro, and iodo substituents on a benzene ring. This strategic combination of halogens enables selective and sequential functionalization via modern transition-metal-catalyzed cross-coupling methodologies, making it an invaluable building block in complex organic synthesis.
Specifications
| Molecular Formula | C6H3BrFI |
|---|---|
| Molecular Weight | 300.895 g/mol |
| Appearance | Transparent colorless to light yellow liquid |
| Density | 1.69 g/cm³ |
| Boiling Point | 231.8°C at 760 mmHg |
| Melting Point | 48–51°C (lit.) |
| Flash Point | >230°F |
| Refractive Index | 1.628 |
| Vapor Pressure | 0.0489 mmHg at 25°C |
| Assay (GC) | ≥99.0% (Typical: 99.46%) |
Industrial Applications
This compound serves primarily as a high-value synthetic intermediate in the development of active pharmaceutical ingredients (APIs), crop protection agents, and advanced materials. Its orthogonal reactivity—where the iodide typically undergoes coupling first due to higher oxidative addition rates, followed by the bromide—allows for precise, stepwise construction of biaryl or heterobiaryl architectures.
- Ideal for Suzuki, Stille, and Sonogashira cross-coupling reactions
- Enables regioselective derivatization in multi-step syntheses
- Used in the preparation of fluorinated bioactive molecules requiring metabolic stability
- Compatible with palladium, nickel, and copper-based catalytic systems
Manufactured under stringent quality control protocols, our 1-bromo-3-fluoro-4-iodobenzene meets global regulatory standards for industrial-scale chemical production and is supplied with comprehensive analytical documentation including Certificate of Analysis (COA).
