1-Bromobut-2-yne
- CAS No.3355-28-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Bromobut-2-yne liquid intermediate for pharmaceutical synthesis. Ideal for Linagliptin and natural product research with reliable supply.
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Product Overview
1-Bromobut-2-yne serves as a versatile and highly reactive alkynyl halide building block within the realm of advanced organic synthesis. This chemical reagent is characterized by its distinct triple bond functionality combined with a bromine leaving group, making it an indispensable tool for constructing complex molecular architectures. Our manufacturing process ensures consistent quality suitable for demanding medicinal chemistry applications and large-scale industrial production.
As a key intermediate, this compound facilitates carbon-carbon bond formation reactions essential for developing novel pharmaceutical agents. The high purity standards maintained during production minimize side reactions, ensuring optimal yields in downstream synthesis processes. We prioritize strict quality control protocols to deliver a product that meets the rigorous expectations of global research laboratories and manufacturing facilities.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 3355-28-0 |
| Molecular Formula | C4H5Br |
| Molecular Weight | 132.99 g/mol |
| Appearance | Colorless to light yellow liquid |
| Purity | ≥97.0% |
| Water Content | <0.5% |
| Density | 1.519 g/cm3 |
| Boiling Point | 40-41 °C at 20 mm Hg |
| Refractive Index | 1.490 |
Industrial Applications
This alkynyl bromide is extensively utilized in the synthesis of heterocyclic compounds, particularly in reactions involving indoles to form annulated ring systems. Such structures are foundational in the development of bioactive molecules. Notably, 1-Bromobut-2-yne acts as a critical precursor in the preparation of Pseudopterane derivatives, including the marine natural product Kallolide B, highlighting its utility in natural product total synthesis.
Furthermore, this intermediate plays a significant role in the manufacturing process of Linagliptin, a prominent pharmaceutical agent used in diabetes management. Its reliability as a synthesis route component ensures that final drug substances meet regulatory compliance standards. Researchers value this chemical for its predictable reactivity profile, which allows for precise control over stereochemistry and functional group tolerance during multi-step synthesis pathways.
Quality Assurance and Storage
We employ advanced analytical techniques to verify the identity and purity of every batch produced. Each shipment is accompanied by a Certificate of Analysis (COA) detailing comprehensive test results. To maintain stability, the product should be stored at room temperature in a ventilated, dry place, protected from light and moisture. Proper sealing is essential to prevent degradation.
Packaging options include 25kg cardboard drums or customized solutions based on specific customer requirements. Our logistics network supports global shipping, ensuring timely delivery while maintaining product integrity throughout transit. For bulk pricing inquiries or technical support regarding synthesis routes, our team of experts is available to assist with your project needs.
