Intermediates

1-(Difluoromethoxy)-2-nitrobenzene

  • CAS No.22225-77-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1-(Difluoromethoxy)-2-nitrobenzene (CAS 22225-77-0) supplied for advanced organic synthesis. Reliable quality assured.

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Product Technical Details

Product Overview

1-(Difluoromethoxy)-2-nitrobenzene is a specialized fluorinated aromatic compound designed for use as a critical intermediate in complex organic synthesis pathways. This chemical entity features a unique difluoromethoxy group attached to a nitrobenzene backbone, providing distinct reactivity profiles essential for modern pharmaceutical and agrochemical research. Our manufacturing process ensures consistent molecular integrity and high purity levels, making it a reliable choice for large-scale production environments.

As a key building block, this compound facilitates the introduction of fluorine atoms into molecular structures, which is a strategic modification known to enhance metabolic stability and bioavailability in downstream applications. The presence of the nitro group further allows for versatile reduction and substitution reactions, enabling chemists to derive a wide array of functionalized derivatives. We prioritize strict quality control measures to guarantee that every batch meets rigorous international standards.

Technical Specifications

The following table outlines the critical physical and chemical properties of 1-(Difluoromethoxy)-2-nitrobenzene. These parameters are verified through advanced analytical techniques including gas chromatography and nuclear magnetic resonance spectroscopy.

ParameterValue
CAS Number22225-77-0
Molecular FormulaC7H5F2NO3
Molecular Weight189.116 g/mol
AppearanceLight yellow liquid
Assay (Purity)≥98.0%
Density1.4±0.1 g/cm3
Boiling Point249.4±30.0 °C at 760 mmHg
Flash Point104.6±24.6 °C
Vapour Pressure0.0±0.5 mmHg at 25°C
Index of Refraction1.494

Industrial Applications

This fluorinated intermediate is primarily utilized in the synthesis of high-value organic compounds. Its stability and reactivity make it suitable for multi-step synthesis routes required in the development of novel active ingredients. Researchers leverage this material to construct complex molecular architectures where precise fluorination is necessary. The compound serves as a precursor in the manufacturing of specialized chemicals used across various industrial sectors.

Furthermore, the high purity specification ensures minimal side reactions during synthesis, optimizing yield and reducing purification costs. Our supply chain is optimized to support both pilot-scale experiments and full commercial production runs. We work closely with R&D departments to provide technical data that supports regulatory filings and process validation.

Quality Assurance and Packaging

We maintain a comprehensive quality management system to ensure product consistency. Each shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. Our packaging solutions are designed to maintain chemical stability during transit. Standard packaging includes 200 kg drums, but we offer flexible customization to meet specific logistical requirements.

Storage recommendations include keeping the container in a cool, ventilated place away from direct sunlight and incompatible materials. Proper handling procedures should be followed to ensure safety in the workplace. Our team provides ongoing technical support to assist with integration into your specific manufacturing processes. Contact us for detailed safety data sheets and bulk pricing information.