Intermediates

1-Fluoro-3,5-bis(trifluoromethyl)benzene

  • CAS No.35564-19-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1-Fluoro-3,5-bis(trifluoromethyl)benzene (CAS 35564-19-3) designed for advanced organic synthesis. Reliable supply with ≥98.0% assay for pharmaceutical intermediates.

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Product Technical Details

Product Overview

1-Fluoro-3,5-bis(trifluoromethyl)benzene is a highly specialized fluorinated aromatic compound serving as a critical building block in modern organic synthesis. Characterized by its unique substitution pattern, this molecule introduces both fluorine and trifluoromethyl groups into complex chemical structures, significantly enhancing metabolic stability and lipophilicity in downstream pharmaceutical candidates. Our manufacturing process ensures consistent quality and high purity, making it an ideal choice for research and industrial-scale production.

As a key intermediate, this compound is extensively utilized in the development of advanced therapeutic agents and agrochemicals. The presence of multiple fluorine atoms modifies the electronic properties of the benzene ring, facilitating specific nucleophilic substitution reactions required in multi-step synthesis pathways. We adhere to strict quality control protocols to guarantee that every batch meets rigorous international standards for chemical intermediates.

Key Specifications

To ensure transparency and reliability for our industrial partners, we provide comprehensive physical and chemical data for every shipment. The following table outlines the standard specifications for this product, verified through advanced analytical techniques including gas chromatography and nuclear magnetic resonance spectroscopy.

ParameterSpecification
CAS Number35564-19-3
Molecular FormulaC8H3F7
Molecular Weight232.098 g/mol
AppearanceColorless to light yellow transparent liquid
Assay (Purity)≥98.0%
Density1.4±0.1 g/cm3
Boiling Point99.8±35.0 °C at 760 mmHg
Flash Point17.8±17.7 °C
Refractive Index1.368

Industrial Applications

This fluorinated benzene derivative is primarily employed as a versatile intermediate in the pharmaceutical industry. It plays a pivotal role in the synthesis of compounds requiring enhanced bioavailability and resistance to metabolic degradation. The trifluoromethyl groups are particularly valuable in medicinal chemistry for optimizing the pharmacokinetic profiles of new drug entities.

Beyond pharmaceuticals, this chemical finds applications in material science and agrochemical formulation. Its stability under various reaction conditions allows chemists to utilize it in diverse synthetic routes, including cross-coupling reactions and nucleophilic aromatic substitutions. Our team supports clients with technical guidance to ensure optimal integration into their specific manufacturing processes.

Quality Assurance and Handling

We understand that consistency is paramount in chemical manufacturing. Each production batch undergoes stringent testing to verify identity and purity. A Certificate of Analysis (COA) is provided with every order, detailing the results of our quality control checks. This documentation ensures full traceability and compliance with your internal quality standards.

For safe handling, the product should be stored in a cool, ventilated area away from incompatible materials. We offer flexible packaging options, including standard 200 kg drums or custom configurations based on logistical requirements. Our global supply chain capabilities ensure timely delivery to support your production schedules without interruption.