Intermediates

1-Fluoro-3,5-Dimethylbenzene

  • CAS No.461-97-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 1-Fluoro-3,5-Dimethylbenzene (CAS 461-97-2) designed for advanced organic synthesis. Reliable supply with comprehensive COA and global shipping options.

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Product Technical Details

Product Overview

1-Fluoro-3,5-Dimethylbenzene is a premium fluorinated aromatic intermediate essential for modern chemical synthesis. Characterized by its meta-substituted structure, this compound serves as a critical building block in the development of complex pharmaceutical agents, agrochemical formulations, and advanced functional materials. Our manufacturing process ensures exceptional consistency and purity, meeting the rigorous demands of industrial research and production environments.

As a key member of the fluoroxylene family, this chemical offers unique reactivity profiles due to the electron-withdrawing nature of the fluorine atom combined with the steric effects of the methyl groups. This balance makes it an ideal candidate for nucleophilic aromatic substitution reactions and cross-coupling processes widely used in medicinal chemistry.

Physical and Chemical Properties

The compound presents as a colorless transparent liquid under standard conditions, facilitating easy handling and integration into various reaction systems. Its physical constants are tightly controlled to ensure reproducible results in downstream applications. The high volatility and specific boiling point allow for efficient purification via distillation when necessary.

ParameterValue
CAS Number461-97-2
Molecular FormulaC8H9F
Molecular Weight124.156
AppearanceColorless transparent liquid
Assay≥98.0%
Density1.0±0.1 g/cm3
Boiling Point147.4±9.0 °C at 760 mmHg
Flash Point32.8±6.2 °C
Refractive Index1.481

Industrial Applications

This fluorinated intermediate is extensively utilized in the synthesis of active pharmaceutical ingredients (APIs). The introduction of fluorine into organic molecules often enhances metabolic stability and bioavailability, making this precursor valuable for drug discovery programs. Additionally, it finds application in the production of agrochemicals where specific substitution patterns are required for biological activity.

Beyond life sciences, 1-Fluoro-3,5-Dimethylbenzene is employed in the manufacture of liquid crystals and polymeric materials. Its chemical stability and solubility characteristics make it suitable for use in specialty coatings and electronic chemicals. Researchers value this compound for its reliability in forming carbon-carbon and carbon-heteroatom bonds.

Quality Assurance and Safety

We adhere to strict quality control protocols throughout the manufacturing lifecycle. Every batch undergoes comprehensive analysis using gas chromatography and other advanced techniques to verify purity levels exceeding 98.0%. A Certificate of Analysis (COA) is provided with each shipment to document compliance with specifications.

  • Consistent supply chain management for bulk orders.
  • Secure packaging in 200 kg drums or customized containers.
  • Storage recommendations include cool, ventilated areas away from ignition sources.
  • Full regulatory support and safety data sheets available upon request.

Our commitment to safety extends to packaging and logistics. We ensure that all materials are labeled correctly according to international transport regulations. For large-scale production needs, our technical team offers support on synthesis routes and process optimization to maximize yield and efficiency.