1-Fluoro-4-(trifluoromethoxy)benzene
- CAS No.352-67-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Fluoro-4-(trifluoromethoxy)benzene (CAS 352-67-0) is a colorless liquid intermediate designed for advanced organic synthesis. Manufactured with ≥99.0% purity to meet strict industrial standards.
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Product Overview
1-Fluoro-4-(trifluoromethoxy)benzene is a specialized fluorinated aromatic compound widely recognized for its stability and reactivity in complex chemical transformations. As a key building block in modern organic synthesis, this substance features a unique structural combination of a fluorine atom and a trifluoromethoxy group on a benzene ring. This specific substitution pattern enhances the lipophilicity and metabolic stability of downstream molecules, making it highly valuable in the development of advanced pharmaceutical agents and agrochemical formulations.
Our manufacturing process ensures exceptional consistency and quality. The compound is produced under strictly controlled conditions to minimize impurities, resulting in a colorless clear liquid that meets rigorous international specifications. The presence of the trifluoromethoxy moiety offers distinct electronic properties that facilitate various nucleophilic substitution reactions, enabling chemists to construct sophisticated molecular architectures with precision.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 1-Fluoro-4-(trifluoromethoxy)benzene |
| CAS Number | 352-67-0 |
| Molecular Formula | C7H4F4O |
| Molecular Weight | 180.10 g/mol |
| Appearance | Colorless clear liquid |
| Purity (GC) | ≥99.0% |
| Density | 1.323 g/cm³ |
| Boiling Point | 104-105°C |
| Flash Point | 15°C |
| Refractive Index | 1.394 |
Industrial Applications
This fluorinated intermediate serves as a critical precursor in multiple high-value industries. In the pharmaceutical sector, it is utilized to introduce fluorine atoms into drug candidates, a strategy often employed to improve bioavailability and binding affinity. The trifluoromethoxy group acts as a bioisostere for methoxy or other alkoxy groups, providing enhanced metabolic resistance against oxidative degradation.
Beyond pharmaceuticals, this compound finds application in the synthesis of advanced agrochemicals, where stability under environmental conditions is paramount. It is also employed in material science research for developing novel polymers and liquid crystals. The versatility of this chemical allows it to participate in various coupling reactions, including Suzuki, Heck, and nucleophilic aromatic substitutions, providing chemists with a flexible tool for molecular design.
Quality Assurance and Packaging
We maintain a robust quality management system to guarantee product integrity. Every batch undergoes comprehensive testing using gas chromatography and other analytical methods to verify purity and identity. A Certificate of Analysis (COA) is provided with each shipment to ensure transparency and compliance with purchase specifications.
- Strict quality control protocols at every production stage.
- Advanced analytical testing for impurity profiling.
- Secure packaging to prevent contamination during transit.
- Customized packaging solutions available upon request.
For storage, the product should be kept in a cool, ventilated area away from direct sunlight and incompatible materials. Standard packaging includes 200 kg drums, though we accommodate specific customer requirements for bulk or smaller quantities. As a global manufacturer, we are committed to supplying reliable chemical intermediates that support innovation and efficiency in your synthesis processes.
