Intermediates

1-Fluoro-8-iodooctane

  • CAS No.1189187-93-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 1-Fluoro-8-iodooctane (CAS 1189187-93-6) is a versatile bifunctional alkylating agent widely used as an intermediate in advanced organic synthesis.

Request Bulk Pricing

Product Technical Details

Product Overview

1-Fluoro-8-iodooctane is a high-purity, bifunctional halogenated aliphatic compound featuring both fluorine and iodine termini on an eight-carbon linear chain. This unique molecular architecture enables its strategic use as a building block in multi-step organic syntheses, particularly in the construction of complex molecular scaffolds requiring orthogonal reactivity. As a specialty intermediate, it supports the development of novel pharmaceuticals, agrochemicals, and functional materials through selective nucleophilic substitution or cross-coupling reactions.

Specifications

Molecular FormulaC8H16FI
Molecular Weight258.12 g/mol
AppearanceColorless transparent liquid
Assay≥99.0%
Moisture≤0.05%
Density1.4 ± 0.1 g/cm³
Boiling Point244.8 ± 8.0 °C
Flash Point105.4 ± 2.6 °C
Refractive Index1.477

Industrial Applications

This compound serves primarily as a dual-functionalized intermediate in research and industrial-scale organic chemistry. Its iodine moiety offers excellent leaving-group capability for palladium-catalyzed couplings (e.g., Suzuki, Sonogashira), while the terminal fluorine provides metabolic stability or polarity modulation in target molecules. Key application areas include:

  • Synthesis of long-chain fluorinated surfactants and polymers
  • Preparation of heterobifunctional linkers for bioconjugation chemistry
  • Construction of macrocyclic frameworks in medicinal chemistry
  • Development of novel liquid crystals or electronic materials

Stored in a cool, well-ventilated area away from light and moisture, 1-Fluoro-8-iodooctane is typically supplied in 200 kg drums or customized packaging to meet GMP and regulatory standards for chemical intermediates.