1-Hydroxybenzotriazole
- CAS No.2592-95-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Hydroxybenzotriazole (CAS 2592-95-2), a widely used coupling additive in peptide and organic synthesis. Supplied as an off-white crystalline powder with ≥99.0% HPLC purity.
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Product Overview
1-Hydroxybenzotriazole (HOBT), with the chemical formula C6H5N3O and CAS number 2592-95-2, is a critical auxiliary reagent in modern organic and peptide synthesis. It functions primarily as an additive to suppress racemization and enhance coupling efficiency when used in conjunction with carbodiimide-based condensing agents such as DCC or EDC. Its molecular structure enables the formation of active ester intermediates, significantly improving reaction yields and selectivity in complex molecule assembly.
Specifications
| Molecular Formula | C6H5N3O |
|---|---|
| Molecular Weight | 135.12 g/mol |
| Melting Point | 156–159 °C |
| Boiling Point | 149–150 °C (decomposes) |
| Density | 1.0 g/cm³ |
| Appearance | Off-white to white crystalline powder |
| Purity (HPLC) | ≥99.0% |
| HS Code | 2933990099 |
| UN Number | UN1325 |
| Hazard Class | 4.1 (Flammable solids) |
| Packing Group | III |
Industrial Applications
As a non-nucleophilic additive, 1-Hydroxybenzotriazole is indispensable in solid-phase and solution-phase peptide synthesis, where it minimizes epimerization during amino acid activation. Beyond pharmaceutical intermediates, it is employed in the production of agrochemicals, specialty polymers, and fine chemicals requiring high-fidelity amide bond formation. Its compatibility with automated synthesizers and scalability in GMP environments make it a preferred choice for industrial R&D and commercial manufacturing.
- Enhances coupling efficiency in peptide synthesis
- Reduces racemization in chiral molecule construction
- Suitable for both laboratory-scale and bulk production
- Stable under standard storage conditions when kept cool and dry
Standard packaging is 25 kg per fiber drum, with custom packaging available upon request. Store in a cool, well-ventilated area away from heat sources and oxidizing materials.
