1-Iodo-3,5-bis(trifluoromethyl)benzene
- CAS No.328-73-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity fluorinated intermediate for advanced organic synthesis. Available in bulk with strict QC and global shipping options.
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Product Overview
1-Iodo-3,5-bis(trifluoromethyl)benzene is a highly specialized fluorinated aromatic compound designed for use in complex organic synthesis pathways. As a key building block, this substance features a benzene ring substituted with an iodine atom and two trifluoromethyl groups, providing unique electronic properties that are essential for modern medicinal and agrochemical research. Our facility produces this intermediate under strict quality control standards to ensure consistency and reliability for downstream applications.
The presence of the trifluoromethyl groups significantly enhances the lipophilicity and metabolic stability of final pharmaceutical products, making this compound a valuable asset for drug discovery teams. The iodo substituent offers excellent reactivity in cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, allowing chemists to construct diverse molecular architectures efficiently.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 328-73-4 |
| Molecular Formula | C8H3F6I |
| Molecular Weight | 340.004 g/mol |
| Appearance | Light yellow liquid |
| Assay (Purity) | ≥98.0% |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 183.9±35.0 °C at 760 mmHg |
| Flash Point | 74.4±0.0 °C |
| Refractive Index | 1.462 |
Industrial Applications
This fluorinated intermediate is primarily utilized in the synthesis of advanced pharmaceutical APIs and high-performance agrochemicals. The electron-withdrawing nature of the trifluoromethyl groups modulates the electronic density of the aromatic ring, facilitating specific nucleophilic substitutions. Researchers value this compound for its ability to serve as a precursor in the development of kinase inhibitors and other targeted therapies.
- Medicinal Chemistry: Used as a core scaffold for constructing bioactive molecules.
- Agrochemical Synthesis: Employed in the production of herbicides and pesticides with enhanced environmental stability.
- Material Science: Applicable in the development of specialized polymers and liquid crystals.
Quality Assurance and Safety
We adhere to rigorous manufacturing processes to maintain industrial purity levels. Each batch undergoes comprehensive testing using GC, HPLC, and NMR spectroscopy to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to ensure compliance with your internal quality standards. Our production facility follows international safety guidelines to handle fluorinated compounds responsibly.
Packaging and Storage
To preserve stability and prevent degradation, 1-Iodo-3,5-bis(trifluoromethyl)benzene is packaged in secure 200 kg drums. Custom packaging solutions are available upon request to meet specific logistical requirements. The product should be stored in a cool, ventilated area away from direct sunlight and incompatible materials. Proper handling procedures must be followed to ensure safety during transport and usage.
