1-Iodo-4-(trifluoromethoxy)benzene
- CAS No.103962-05-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Iodo-4-(trifluoromethoxy)benzene (CAS 103962-05-6) designed for advanced organic synthesis. Reliable supply with ≥99.0% GC purity for pharmaceutical and chemical manufacturing.
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Product Overview
1-Iodo-4-(trifluoromethoxy)benzene is a specialized fluorinated aromatic compound widely utilized in modern organic synthesis and pharmaceutical development. This aryl iodide derivative features a trifluoromethoxy group positioned para to the iodine substituent, offering unique electronic and steric properties that enhance reactivity in cross-coupling reactions. Our manufacturing process ensures consistent quality and high purity levels suitable for demanding research and industrial applications.
As a key building block, this compound serves as a critical precursor in the construction of complex molecular architectures. The presence of the trifluoromethoxy moiety often improves metabolic stability and lipophilicity in final drug candidates, making this intermediate highly valuable for medicinal chemistry programs. We maintain strict quality control protocols to guarantee that every batch meets rigorous international standards.
Key Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 1-Iodo-4-(trifluoromethoxy)benzene |
| CAS Number | 103962-05-6 |
| Molecular Formula | C7H4F3IO |
| Molecular Weight | 288.01 g/mol |
| Appearance | Almost colourless clear liquid |
| Purity (GC) | ≥99.0% |
| Density | 1.84 g/cm³ |
| Boiling Point | 177-179°C |
| Refractive Index | 1.504 |
Industrial Applications
This fluorinated intermediate is primarily employed in the synthesis of advanced pharmaceutical agents and agrochemicals. The iodine atom facilitates palladium-catalyzed coupling reactions such as Suzuki, Heck, and Sonogashira couplings, enabling the efficient formation of carbon-carbon bonds. Researchers utilize this material to introduce trifluoromethoxy groups into lead compounds, optimizing their pharmacokinetic profiles.
- Pharmaceutical intermediate for novel drug discovery
- Building block for fluorinated organic materials
- Reagent in cross-coupling synthetic routes
- Component in agrochemical formulation development
Quality Assurance and Packaging
We understand the importance of reliability in the supply chain. Each production lot undergoes comprehensive analysis using gas chromatography and nuclear magnetic resonance spectroscopy to verify identity and purity. A Certificate of Analysis (COA) is provided with every shipment to ensure transparency and compliance with your internal quality standards. Our facility operates under strict safety and environmental guidelines.
Standard packaging consists of 200 kg drums, ensuring safe transport and storage. Customized packaging solutions are available upon request to accommodate specific logistical requirements or smaller scale research needs. We strive to offer competitive bulk pricing without compromising on product integrity or delivery timelines.
Storage and Handling
To maintain optimal stability, 1-Iodo-4-(trifluoromethoxy)benzene should be stored in a cool, ventilated area away from direct sunlight and heat sources. Containers must remain tightly sealed when not in use to prevent moisture absorption or contamination. Proper personal protective equipment, including gloves and safety goggles, is recommended during handling to ensure personnel safety. Always refer to the Safety Data Sheet (SDS) for detailed hazard information and emergency procedures.
