1-Isocyanato-4-methylcyclohexane
- CAS No.32175-00-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1-Isocyanato-4-methylcyclohexane (CAS 32175-00-1), a key pharmaceutical intermediate for advanced synthetic applications.
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Product Overview
1-Isocyanato-4-methylcyclohexane (CAS 32175-00-1) is a high-value cycloaliphatic isocyanate widely employed as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs). This compound features a trans-configured methylcyclohexyl backbone linked to a reactive isocyanate functional group, offering excellent stability and selectivity in multi-step organic transformations. Its structural rigidity and controlled reactivity make it particularly suitable for constructing heterocyclic scaffolds found in modern therapeutic agents.
Specifications
| Molecular Formula | C8H13NO |
|---|---|
| Molecular Weight | 139.195 g/mol |
| Appearance | Colorless to light yellow liquid |
| Assay | ≥98.0% |
| Density | 1.0 ± 0.1 g/cm³ |
| Boiling Point | 182.2 ± 9.0 °C at 760 mmHg |
| Flash Point | 60.1 ± 21.3 °C |
| Vapour Pressure | 0.8 ± 0.3 mmHg at 25°C |
| Refractive Index | 1.519 |
Industrial Applications
Primarily utilized as a specialized intermediate in the pharmaceutical manufacturing sector, 1-Isocyanato-4-methylcyclohexane serves as a key precursor in the synthesis of advanced therapeutic molecules. It has been documented in synthetic routes toward sulfonylurea-class antidiabetic agents, where its cycloaliphatic structure contributes to metabolic stability and target specificity. Due to the high reactivity of the isocyanate group, this compound enables efficient urea or carbamate bond formation under controlled conditions, facilitating the construction of pharmacologically active cores.
- Enables precise stereochemical control in API synthesis
- Offers enhanced thermal and hydrolytic stability compared to aromatic isocyanates
- Compatible with standard industrial handling protocols for moisture-sensitive intermediates
Stored in a cool, well-ventilated area away from moisture and heat sources, this product is typically supplied in 200 kg drums or customized packaging to meet client-specific logistical requirements. As a moisture-sensitive chemical, strict adherence to anhydrous handling practices is essential to maintain assay integrity and performance consistency.
