1-Methylindole
- CAS No.603-76-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 1-Methylindole (CAS 603-76-9) designed for pharmaceutical synthesis, specifically as a key intermediate for Osimertinib production.
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Product Overview
1-Methylindole represents a critical component in the landscape of modern pharmaceutical chemistry. As a specialized heterocyclic compound, this substance serves as an essential building block for the synthesis of complex therapeutic agents. Our facility produces this chemical with a focus on exceptional purity and consistency, catering to the rigorous demands of pharmaceutical research and development teams worldwide. The molecular structure features a methyl group substituted at the nitrogen position of the indole ring, which significantly influences its reactivity and stability in subsequent synthetic pathways.
We understand that reliability in the supply chain is paramount for continuous production schedules. Therefore, our manufacturing processes are optimized to ensure batch-to-batch reproducibility. This product is particularly valued in the development of kinase inhibitors and other targeted therapies where precise chemical architecture is required to achieve desired biological activity.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 603-76-9 |
| Molecular Formula | C9H9N |
| Molecular Weight | 131.174 g/mol |
| Appearance | Brown transparent liquid |
| Assay (Purity) | ≥98.0% |
| Boiling Point | 239.4±9.0 °C at 760 mmHg |
| Melting Point | 94 - 95ºC |
| Density | 1.0±0.1 g/cm3 |
| Flash Point | 98.6±18.7 °C |
Industrial Applications
The primary application of 1-Methylindole lies in its role as a sophisticated intermediate for the synthesis of Osimertinib, a third-generation epidermal growth factor receptor (EGFR) inhibitor used in oncology treatments. The chemical properties of this compound allow for efficient coupling reactions and structural modifications necessary for constructing the final active pharmaceutical ingredient. Beyond this specific application, it is utilized in various organic synthesis routes where an N-methylated indole scaffold is required.
Research laboratories utilize this material for screening programs and process development. Its high purity level minimizes the formation of unwanted by-products during synthesis, thereby improving overall yield and reducing downstream purification costs. This efficiency makes it a preferred choice for scale-up operations moving from clinical trials to commercial manufacturing.
Quality Assurance And Logistics
Quality control is integrated at every stage of our production cycle. Each batch undergoes comprehensive analysis using advanced chromatographic and spectroscopic methods to verify identity and purity levels. We provide a Certificate of Analysis (COA) with every shipment, ensuring full transparency and compliance with international standards. Our packaging solutions are designed to maintain chemical integrity during transit, utilizing durable drums that protect against moisture and light exposure.
Storage recommendations include keeping the container in a cool, ventilated area away from incompatible substances. We offer flexible packaging options, including standard 200 kg drums or custom configurations based on specific client requirements. Our global logistics network ensures timely delivery to major pharmaceutical hubs, supporting your production timelines with reliable supply chain management.
