Intermediates

1-(trifluoromethyl)cyclopropane-1-carboxylic acid

  • CAS No.277756-46-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity fluorinated building block designed for advanced pharmaceutical and agrochemical synthesis applications.

Request Bulk Pricing

Product Technical Details

Product Overview

1-(trifluoromethyl)cyclopropane-1-carboxylic acid is a specialized fluorinated organic intermediate characterized by its unique cyclopropane ring structure substituted with a trifluoromethyl group. This compound serves as a critical building block in the synthesis of complex molecular architectures, particularly within the pharmaceutical and agrochemical sectors. The incorporation of the trifluoromethyl moiety often enhances metabolic stability and lipophilicity in final drug candidates, making this acid a valuable precursor for medicinal chemistry programs.

Our manufacturing process ensures high chemical purity and consistency, adhering to strict quality control protocols suitable for research and development environments. The stability of the cyclopropane ring combined with the electron-withdrawing nature of the fluorine atoms provides distinct reactivity profiles that are exploited in various coupling and functionalization reactions.

Technical Specifications

ParameterValue
CAS Number277756-46-4
Molecular FormulaC5H5F3O2
Molecular Weight154.09 g/mol
Melting Point86 °C
Boiling Point182-184 °C
Density1.588 g/cm3
Refractive Index1.421
Vapor Pressure1.29 mmHg at 25 °C

Industrial Applications

This fluorinated carboxylic acid is primarily utilized as a key intermediate in the development of new active pharmaceutical ingredients (APIs). Its structural features allow chemists to introduce specific steric and electronic properties into lead compounds. Additionally, it finds application in the synthesis of novel agrochemicals where fluorine substitution is known to improve biological activity and environmental persistence profiles.

Beyond pharmaceuticals, this compound is employed in materials science research for creating fluorinated polymers and specialty chemicals. The robust nature of the carbon-fluorine bonds contributes to the thermal and chemical stability of downstream products, making it suitable for high-performance material applications.

Quality and Supply Assurance

We are committed to providing a complete fluorochemical products and technology platform. Every batch of 1-(trifluoromethyl)cyclopropane-1-carboxylic acid undergoes rigorous analytical testing to verify identity and purity. We provide comprehensive documentation including Certificates of Analysis (COA) to support regulatory compliance and research reproducibility.

  • Consistent industrial purity levels suitable for scale-up
  • Secure packaging to maintain stability during transit
  • Global logistics capabilities for timely delivery
  • Technical support for synthesis route optimization

Our facility integrates fluorine-containing raw material procurement with advanced production technology, ensuring a reliable supply chain for global customers. Whether for small-scale laboratory research or large-scale manufacturing needs, we offer flexible packaging options and competitive bulk pricing structures.