1,2,3,9-Tetrahydro-4(H)-Carbazol-4-One
- CAS No.15128-52-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 1,2,3,9-Tetrahydro-4(H)-Carbazol-4-One (CAS 15128-52-6), a key pharmaceutical intermediate for Carvedilol and Ondansetron synthesis.
Request Bulk PricingProduct Technical Details
Product Overview
1,2,3,9-Tetrahydro-4(H)-Carbazol-4-One (CAS 15128-52-6) is a high-value heterocyclic organic compound widely employed as a critical building block in the synthesis of advanced cardiovascular and antiemetic pharmaceuticals. With a molecular formula of C12H11NO and a molecular weight of 185.22 g/mol, this compound features a fused carbazole core with a ketone functionality, offering versatile reactivity for downstream medicinal chemistry applications.
Specifications
| Molecular Formula | C12H11NO |
|---|---|
| Molecular Weight | 185.22 g/mol |
| Density | 1.275 g/cm³ |
| Boiling Point | 386.3°C at 760 mmHg |
| Melting Point | 224–226°C |
| Flash Point | 194.5°C |
| Refractive Index | 1.689 |
| Appearance | White crystal powder |
| Assay (Purity) | ≥99% |
| Loss on Drying | ≤0.5% |
| Single Impurity | ≤0.5% |
Industrial Applications
This compound serves as a pivotal intermediate in the commercial-scale production of several therapeutically important active pharmaceutical ingredients (APIs). Key applications include:
- Synthesis of Carvedilol (CAS 72956-09-3), a non-selective beta blocker used in hypertension and heart failure management.
- Manufacture of Carvedilol phosphate (CAS 610309-89-2), a water-soluble prodrug derivative.
- Key precursor in the multi-step synthesis of Ondansetron (CAS 99614-02-5) and its hydrochloride salt (CAS 103639-04-9), widely prescribed 5-HT3 receptor antagonists for nausea and vomiting control.
Our product is manufactured under stringent quality control protocols compliant with international pharmacopeial standards, ensuring batch-to-batch consistency and suitability for regulated pharmaceutical development.
Handling and Storage
Store in a cool, dry, and well-closed container. Protect from moisture, direct sunlight, and excessive heat. Standard industrial hygiene practices should be followed during handling.
Packaging
Supplied in 25 kg fiberboard drums with inner polyethylene liners, or customized packaging per client requirements.
