Intermediates

(1R,2R)-(-)-1,2-Cyclohexanedicarboxylic Acid

  • CAS No.46022-05-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity chiral intermediate essential for Lurasidone synthesis, available in bulk with certified quality assurance.

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Product Technical Details

Product Overview

(1R,2R)-(-)-1,2-Cyclohexanedicarboxylic Acid is a highly specialized chiral building block extensively utilized in the pharmaceutical industry for the synthesis of complex active pharmaceutical ingredients. This stereospecific dicarboxylic acid features a trans-configured cyclohexane ring structure, providing the necessary geometric constraints required for advanced organic synthesis. As a critical precursor, it plays an indispensable role in the manufacturing pipeline of modern neurological therapeutics, ensuring high enantiomeric purity throughout the production process.

Our manufacturing facility adheres to strict Good Manufacturing Practices (GMP) to guarantee consistent quality across every batch. The compound is characterized by its stable chemical properties and high reactivity under controlled conditions, making it an ideal candidate for multi-step synthesis routes. We understand the critical nature of supply chain reliability for pharmaceutical manufacturers, and thus we maintain robust inventory levels to support large-scale production requirements globally.

Specifications and Physical Properties

SpecificationStandard
CAS Number46022-05-3
Molecular FormulaC8H12O4
Molecular Weight172.18 g/mol
AppearanceOff-white solid
Assay (Purity)≥98.0%
Melting Point184°C
Density1.315 g/cm3

Industrial Applications

The primary application of this chiral intermediate lies in the synthesis of Lurasidone, an atypical antipsychotic agent. The specific (1R,2R) stereochemistry is crucial for the biological activity of the final drug product. Beyond this specific application, the compound serves as a versatile synthon in the development of various fine chemicals and specialized organic compounds. Its utility extends to research and development laboratories focusing on novel drug discovery where chiral cyclohexane derivatives are required.

  • Key intermediate for antipsychotic pharmaceutical synthesis
  • Essential building block for chiral catalyst development
  • Used in advanced organic synthesis research
  • Compatible with various esterification and amidation reactions

Quality Assurance and Storage

Quality control is paramount in our production process. Each batch undergoes rigorous testing using High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy to verify structural integrity and purity levels. A Certificate of Analysis (COA) is provided with every shipment to ensure full transparency and compliance with international standards. Proper storage is essential to maintain product stability over time.

We recommend storing the material in a cool, ventilated environment away from direct sunlight and moisture. The product is packaged in 25 kg drums as standard, but we offer flexible custom packaging solutions to meet specific logistical needs. Our global distribution network ensures timely delivery while maintaining the integrity of the chemical during transit. For detailed technical data or safety information, please contact our technical support team.