![(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol manufacturer, supplier](/images/2026/15N463940-5G5.png)
(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
- CAS No.225920-05-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity chiral intermediate for the synthesis of antiemetic APIs such as Aprepitant and Fosaprepitant.
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Product Overview
(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a high-value chiral building block widely employed in the pharmaceutical industry as a key intermediate in the synthesis of neurokinin-1 (NK1) receptor antagonists. This enantiomerically enriched compound features exceptional stereochemical integrity and serves as a critical precursor to active pharmaceutical ingredients (APIs) including Aprepitant (CAS 170729-80-3) and its water-soluble prodrug Fosaprepitant (CAS 172673-20-0).
Specifications
| Molecular Formula | C₁₀H₈F₆O |
|---|---|
| Molecular Weight | 258.16 g/mol |
| Appearance | White or off-white powder |
| Assay (GC) | ≥99.0% (Typical: 99.9%) |
| Enantiomeric Excess (ee%) | ≥99.0% (Typical: 99.5%) |
| Melting Point | 50–53 °C |
| Loss on Drying | ≤0.5% |
| Density | 1.4 ± 0.1 g/cm³ |
| Flash Point | 60.1 ± 25.9 °C |
Industrial Applications
This compound is exclusively utilized as a chiral intermediate in advanced pharmaceutical manufacturing processes. Its rigid aromatic backbone bearing two electron-withdrawing trifluoromethyl groups enhances metabolic stability and binding affinity in final drug molecules. Key applications include:
- Synthesis of Aprepitant, a first-in-class antiemetic used to prevent chemotherapy-induced nausea and vomiting.
- Production of Fosaprepitant, the intravenous prodrug formulation offering rapid onset of action in clinical settings.
- Serving as a stereochemically defined scaffold in medicinal chemistry campaigns targeting CNS disorders.
Manufactured under stringent GMP-compliant conditions, our product ensures batch-to-batch consistency, full traceability, and comprehensive documentation including Certificate of Analysis (COA) and safety data sheets. Packaging is available in 25 kg drums or customized configurations upon request. Store in a cool, dry, and well-ventilated area with the container tightly sealed to maintain stability and purity.
