Intermediates

2,6-Difluorophenol

  • CAS No.28177-48-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2,6-Difluorophenol (CAS 28177-48-2) designed for pharmaceutical and agrochemical synthesis. Available in bulk with strict quality control.

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Product Technical Details

Product Overview

2,6-Difluorophenol is a highly valued fluorinated aromatic compound widely utilized in the fine chemical and pharmaceutical industries. As a critical building block, this substance serves as a key precursor in the synthesis of complex organic molecules. Our manufacturing process ensures exceptional purity levels, making it an ideal choice for research and development teams focused on medicinal chemistry and advanced material science. The introduction of fluorine atoms at the ortho positions significantly alters the electronic and steric properties of the phenol ring, enhancing the metabolic stability and bioavailability of downstream pharmaceutical candidates.

Key Specifications

Parameter Value
Chemical Name 2,6-Difluorophenol
CAS Number 28177-48-2
Molecular Formula C6H4F2O
Molecular Weight 130.09 g/mol
Appearance White Crystal
Purity ≥99.0%
Melting Point 38-41 °C
Boiling Point 59-61 °C at 17 mm Hg
Density 1.27 g/cm3
Refractive Index 1.495

Industrial Applications

This fluorinated intermediate plays a pivotal role in the production of various bioactive compounds. It is extensively used in the preparation of isoxazolone-based inhibitors and other therapeutic agents targeting inflammatory pathways. Beyond pharmaceuticals, 2,6-Difluorophenol is employed in agrochemical synthesis to create robust pesticides and herbicides with improved environmental profiles. The compound's unique reactivity allows for versatile functionalization, supporting nucleophilic substitution and coupling reactions essential for constructing diverse chemical libraries. Researchers value this material for its consistency and reliability in multi-step synthesis routes.

Quality Assurance and Manufacturing

Our facility adheres to stringent quality management systems to guarantee product consistency. Every batch undergoes rigorous testing using advanced analytical techniques such as HPLC and GC-MS to verify purity and identity. We provide comprehensive documentation, including Certificates of Analysis (COA), with every shipment. Our commitment to industrial purity standards ensures that customers receive materials suitable for sensitive synthetic applications without the need for further purification. We maintain a robust supply chain to support bulk orders globally, ensuring timely delivery for large-scale production needs.

Storage and Handling

  • Store in a tightly closed container to prevent moisture absorption and contamination.
  • Keep in a cool, dry, and well-ventilated area away from incompatible substances.
  • Maintain storage temperatures between 2-8ºC for optimal stability over extended periods.
  • Handle with appropriate personal protective equipment (PPE) including gloves and safety goggles.
  • Avoid exposure to strong oxidizing agents and direct sunlight during storage.

For detailed safety data sheets (SDS) or technical inquiries regarding custom synthesis capabilities, please contact our professional support team. We are dedicated to supporting your innovation with high-quality chemical solutions.