Intermediates

2-(1,3,2-Dioxaborinan-2-yl)benzonitrile

  • CAS No.172732-52-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-(1,3,2-Dioxaborinan-2-yl)benzonitrile (CAS 172732-52-4) designed for pharmaceutical synthesis. Reliable supply with strict quality control.

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Product Technical Details

Product Overview

2-(1,3,2-Dioxaborinan-2-yl)benzonitrile is a specialized organic compound characterized by its unique boronic acid ester structure combined with a nitrile functional group. This chemical serves as a critical building block in modern medicinal chemistry and advanced organic synthesis. Our manufacturing process ensures exceptional purity and consistency, making it an ideal choice for research and development teams focused on complex pharmaceutical pathways. The compound is particularly valued for its stability and reactivity in cross-coupling reactions.

As a leading global manufacturer, we understand the stringent requirements of the pharmaceutical industry. Therefore, this product is synthesized under rigorous quality management systems to meet international standards. The presence of the dioxaborinan ring provides enhanced stability compared to free boronic acids, facilitating easier handling and storage during multi-step synthesis routes. This feature is essential for maintaining reaction efficiency and yield in large-scale production environments.

Technical Specifications

ParameterValue
CAS Number172732-52-4
Molecular FormulaC10H10BNO2
Molecular Weight187.00 g/mol
AppearanceWhite powder
Assay≥98.0%
Water Content≤0.50%
Density1.13 g/cm3
Boiling Point372.4°C at 760 mmHg
Melting Point46-56°C
Flash Point179°C

Industrial Applications

This boronic acid derivative is primarily utilized as a key intermediate in the synthesis of active pharmaceutical ingredients. It plays a vital role in Suzuki-Miyaura coupling reactions, which are fundamental in constructing biaryl structures found in many modern drugs. Specifically, it is employed in the manufacturing pathways for neurological therapeutics and antiepileptic medications. The nitrile group offers additional versatility for downstream functionalization, allowing chemists to convert it into amines, acids, or other heterocycles as required by the target molecule design.

  • Pharmaceutical intermediate for neurological therapeutics
  • Building block for Suzuki-Miyaura cross-coupling reactions
  • Precursor for complex organic synthesis projects
  • Research and development in medicinal chemistry
  • Custom synthesis for specialized chemical projects

Quality Assurance And Storage

Quality is the cornerstone of our production philosophy. Every batch of 2-(1,3,2-Dioxaborinan-2-yl)benzonitrile undergoes comprehensive testing using advanced analytical techniques such as HPLC, NMR, and Karl Fischer titration. We provide a detailed Certificate of Analysis (COA) with every shipment to verify compliance with specified parameters. Our facility adheres to strict safety protocols to ensure the integrity of the product from synthesis to packaging.

Proper storage is crucial for maintaining the stability of boronic esters. This product should be stored in a cool, dry, and well-ventilated area. Containers must be kept tightly closed to prevent moisture absorption, which can lead to hydrolysis of the boronic ester group. We recommend storing the material at controlled room temperature away from incompatible substances such as strong oxidizers. Following these guidelines ensures the longevity and performance of the chemical in your synthesis processes.

Packaging And Shipping

We offer flexible packaging solutions to meet the diverse needs of our global clientele. The standard package is 25kg per drum, which is optimized for safe transport and handling. However, we can customize packaging according to specific customer requirements to facilitate integration into your production line. Our logistics team ensures timely delivery while complying with all international transport regulations for chemical substances. Safety data sheets and all necessary documentation are provided to ensure smooth customs clearance and safe handling upon arrival.