2-(3,4-Dimethylphenyl)-5-methyl-4H-pyrazol-3-one
- CAS No.18048-64-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity pharmaceutical intermediate used primarily in the synthesis of Eltrombopag. Available in bulk quantities with full documentation.
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Product Overview
2-(3,4-Dimethylphenyl)-5-methyl-4H-pyrazol-3-one is a specialized organic compound serving as a critical building block in modern medicinal chemistry. Identified by CAS number 18048-64-1, this pyrazolone derivative is extensively utilized in the pharmaceutical industry for the construction of complex active pharmaceutical ingredients (APIs). Our facility produces this intermediate under strict quality control standards to ensure consistency and reliability for downstream synthesis processes.
The compound features a distinct dimethylphenyl substitution pattern on the pyrazolone ring, which imparts specific reactivity profiles essential for targeted chemical transformations. As a key precursor, it plays a vital role in the manufacturing workflow of thrombopoietin receptor agonists, specifically contributing to the structural framework of Eltrombopag. Our production capabilities are designed to meet the rigorous demands of global pharmaceutical supply chains.
Key Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 2-(3,4-Dimethylphenyl)-5-methyl-4H-pyrazol-3-one |
| CAS Number | 18048-64-1 |
| Molecular Formula | C12H14N2O |
| Molecular Weight | 202.252 g/mol |
| Appearance | White crystalline powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 116-119°C |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 338.5±52.0 °C at 760 mmHg |
| Flash Point | 158.5±30.7 °C |
Industrial Applications
This chemical intermediate is primarily designated for use in the synthesis of advanced therapeutic agents. Its primary application lies in the production chain of Eltrombopag, a medication used to treat thrombocytopenia. The high purity level ensures minimal impurity carryover into the final API, facilitating smoother regulatory approval processes for downstream manufacturers. Beyond this specific application, the pyrazolone scaffold is valuable in various research and development contexts involving heterocyclic chemistry.
Chemists utilize this material for coupling reactions and structural modifications required to achieve the final pharmacological profile. The stability of the compound under standard storage conditions makes it suitable for international shipping and long-term inventory management within GMP-compliant facilities.
Quality Assurance and Handling
- Manufactured in compliance with international quality management systems.
- Each batch is accompanied by a comprehensive Certificate of Analysis (COA).
- Advanced analytical testing includes HPLC, NMR, and mass spectrometry verification.
- Packaged in 25 kg drums or customized containers based on client logistics requirements.
- Storage recommendations include keeping the material in a cool, ventilated area away from direct sunlight.
We are committed to providing reliable supply solutions for pharmaceutical intermediates. Our team supports clients with technical data, safety documentation, and flexible packaging options to streamline your procurement process. For bulk inquiries and specific purity requirements, please contact our sales department for a detailed quotation and lead time information.
