Intermediates

2-(2,2,2-Trifluoroethoxy)phenol

  • CAS No.160968-99-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate designed for Silodosin synthesis. Offers excellent stability and reactivity for large-scale production.

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Product Technical Details

Product Overview

2-(2,2,2-Trifluoroethoxy)phenol is a specialized fluorinated aromatic ether compound that plays a critical role in modern medicinal chemistry and pharmaceutical manufacturing. As a key building block, this chemical intermediate is primarily utilized in the synthesis of advanced therapeutic agents, including alpha-adrenergic receptor antagonists. The incorporation of the trifluoroethoxy group enhances the metabolic stability and lipophilicity of the final drug molecule, making it a highly valued component in complex organic synthesis pathways.

Our manufacturing facility produces this compound under strict quality control standards to ensure consistency and reliability for downstream pharmaceutical applications. We understand the critical nature of supply chain stability in the drug development sector and maintain robust inventory levels to support both research-scale and commercial-scale production needs.

Technical Specifications

The following table outlines the key physical and chemical properties of our premium grade 2-(2,2,2-Trifluoroethoxy)phenol. Each batch is rigorously tested to meet or exceed these specifications.

ParameterSpecification
CAS Number160968-99-0
Molecular FormulaC8H7F3O2
Molecular Weight192.135 g/mol
AppearanceOff-white to light grey powder
Assay (Purity)≥98.0%
Melting Point49-50 °C
Boiling Point202.5±40.0 °C at 760 mmHg
Density1.3±0.1 g/cm3
Flash Point101.7±23.8 °C

Industrial Applications

This fluorinated phenol derivative is predominantly employed as a crucial intermediate in the manufacturing of Silodosin, a pharmaceutical agent used in urological treatments. Beyond this specific application, the compound serves as a versatile reagent in the development of various fluorinated organic compounds. The unique electronic properties of the trifluoromethyl group allow chemists to fine-tune the pharmacokinetic profiles of new drug candidates.

Researchers and process chemists value this intermediate for its reactivity in nucleophilic substitution reactions and ether formation. It is an essential component for laboratories focusing on the creation of novel therapeutic molecules where fluorine substitution is required to improve bioavailability and binding affinity.

Quality Assurance and Safety

Quality is the cornerstone of our chemical manufacturing process. Every production batch of 2-(2,2,2-Trifluoroethoxy)phenol undergoes comprehensive analytical testing using high-performance liquid chromatography (HPLC), gas chromatography (GC), and nuclear magnetic resonance (NMR) spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full transparency regarding purity and impurity profiles.

Safety data sheets (SDS) are available upon request, outlining proper handling procedures. While this compound is intended for industrial and laboratory use, standard personal protective equipment (PPE) should be worn during handling to prevent inhalation or skin contact. Our facility adheres to international environmental and safety regulations to minimize ecological impact.

Packaging and Logistics

To maintain product integrity during transit, 2-(2,2,2-Trifluoroethoxy)phenol is packaged in secure 25 kg drums lined with protective materials. Custom packaging solutions are available to meet specific customer requirements or logistical constraints. We recommend storing the product in a cool, ventilated area away from direct sunlight and moisture to preserve its chemical stability over time.

As a global manufacturer, we offer efficient shipping options to destinations worldwide. Our logistics team ensures that all documentation is compliant with international chemical transport regulations. For bulk orders or long-term supply agreements, please contact our sales department for competitive pricing and lead time information.