2,3,4-Trifluoronitrobenzene

Product Overview

2,3,4-Trifluoronitrobenzene is a highly specialized aromatic fluoride compound that serves as a critical building block in modern organic synthesis. Identified by CAS number 771-69-7, this chemical intermediate is characterized by its unique substitution pattern of fluorine and nitro groups on the benzene ring. This specific arrangement enhances its reactivity in nucleophilic aromatic substitution reactions, making it an indispensable precursor for the development of advanced pharmaceutical agents and agrochemical products.

Our manufacturing facility produces this compound under stringent quality management systems to ensure consistent batch-to-batch reliability. As a key player in the global supply chain for fluorinated intermediates, we understand the precision required by research laboratories and industrial production lines. The compound is supplied as a pale yellow transparent liquid, ready for immediate integration into complex synthetic routes.

Physical and Chemical Properties

Understanding the physicochemical profile of 2,3,4-Trifluoronitrobenzene is essential for safe handling and optimal process design. The substance exhibits a density of approximately 1.541 g/cm³, indicating a relatively heavy molecular structure typical of polyfluorinated aromatics. With a boiling point around 92°C under reduced pressure conditions, it requires careful distillation protocols during purification. The flash point is recorded at 200°F, necessitating standard flammable liquid storage precautions. Additionally, the refractive index of 1.492 serves as a key identifier for purity verification during incoming quality checks.

Industrial Applications

The primary application of this fluorinated intermediate lies in the pharmaceutical sector, specifically within the synthesis of quinolone antibiotics. It acts as a vital precursor for therapeutic agents such as ofloxacin and lomefloxacin. The introduction of fluorine atoms into drug molecules often improves metabolic stability and bioavailability, which is why high-purity fluorinated building blocks are in constant demand. Beyond pharmaceuticals, this compound is utilized in the development of novel agrochemicals and functional materials where electron-withdrawing groups are required to modulate chemical reactivity.

Quality Specifications

We adhere to rigorous analytical standards to guarantee the performance of our chemicals. Each batch undergoes comprehensive testing using Gas Chromatography (GC) and High-Performance Liquid Chromatography (HPLC) to confirm assay levels. The standard specification requires an assay of ≥99.0%, ensuring minimal impurity interference in downstream reactions. Moisture content is strictly controlled at ≤0.2% to prevent hydrolysis or side reactions during storage and usage. A Certificate of Analysis (COA) is provided with every shipment to document compliance with these parameters.

Safety and Storage

Proper handling procedures are mandatory when working with 2,3,4-Trifluoronitrobenzene. Personnel should wear appropriate personal protective equipment, including chemical-resistant gloves and safety goggles. The product must be stored in a cool, ventilated place away from direct sunlight and incompatible materials such as strong oxidizing agents. We offer flexible packaging options, typically supplying 200 kg per drum, but can accommodate custom packaging requirements based on specific logistical needs. Our team is dedicated to supporting your synthesis goals with reliable supply and technical expertise.