2',3',5'-Triacetyl-azacytidine
- CAS No.10302-78-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2',3',5'-Triacetyl-azacytidine (CAS 10302-78-0), a key nucleoside intermediate for the synthesis of epigenetic therapeutics and DNMT inhibitors.
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Product Overview
2',3',5'-Triacetyl-azacytidine is a chemically protected derivative of 5-azacytidine, widely employed as a critical synthetic intermediate in the pharmaceutical industry. With the CAS number 10302-78-0 and molecular formula C14H18N4O8, this compound serves as a prodrug precursor in the production of azacitidine—a clinically approved DNA methyltransferase (DNMT) inhibitor used in the management of myelodysplastic syndromes and other hematological malignancies. Its acetylated ribofuranosyl structure enhances stability during synthetic processing, making it indispensable in advanced nucleoside chemistry.
Specifications
| Molecular Formula | C14H18N4O8 |
|---|---|
| Molecular Weight | 370.32 g/mol |
| Density | 1.6 g/cm³ |
| Boiling Point | 497.3°C |
| Flash Point | 254.6°C |
| Refractive Index | 1.633 |
| Appearance | White to off-white crystalline powder |
| Assay (HPLC) | ≥98.0% |
Industrial Applications
This compound is primarily utilized in the multi-step synthesis of epigenetic modulators and antineoplastic agents. Key applications include:
- Serving as a protected building block in solid-phase and solution-phase oligonucleotide synthesis.
- Facilitating the controlled deprotection and conversion to active pharmaceutical ingredients (APIs) such as azacitidine.
- Supporting research in oncology, hematology, and epigenetics through reliable, high-purity material supply.
Stored in a cool, well-ventilated environment, 2',3',5'-Triacetyl-azacytidine maintains its integrity under standard industrial handling conditions. It is typically packed in 25 kg drums or customized packaging per client specifications, ensuring global logistics compliance and batch traceability.
