2,3-Dimethyl-2H-indazol-6-amine Hydrochloride

Product Overview

2,3-Dimethyl-2H-indazol-6-amine Hydrochloride is a critical pharmaceutical intermediate utilized extensively in the synthesis of advanced kinase inhibitors. This compound, identified by CAS number 635702-60-2, serves as a foundational building block in the manufacturing process of Pazopanib, a notable therapeutic agent used in oncology treatments. Our facility specializes in the production of this high-quality chemical entity, ensuring that every batch meets rigorous international standards for pharmaceutical synthesis.

As a leading global manufacturer, we understand the importance of consistency and purity in the supply chain of active pharmaceutical ingredients (APIs). This product is synthesized using optimized reaction pathways that maximize yield while minimizing impurities. The hydrochloride salt form enhances stability and solubility, making it an ideal candidate for downstream chemical transformations required in complex drug synthesis.

Quality Specifications and Analysis

Quality assurance is the cornerstone of our manufacturing philosophy. Each production lot undergoes comprehensive analytical testing to verify compliance with specified parameters. We employ advanced chromatographic and spectroscopic methods to confirm identity and purity. The following table outlines the typical specification profile and test results for our standard production batches:

The data demonstrates our commitment to delivering material that exceeds minimum purity requirements. With an assay typically reaching 99.2% and minimal moisture content, this intermediate supports efficient downstream processing without the need for extensive purification steps.

Industrial Applications

The primary application of 2,3-Dimethyl-2H-indazol-6-amine Hydrochloride is in the pharmaceutical sector, specifically as a key intermediate for Pazopanib. Pazopanib is a multi-tyrosine kinase inhibitor used in the treatment of advanced renal cell carcinoma and soft tissue sarcoma. The precision required in synthesizing such potent therapeutics demands starting materials of exceptional quality. Our product ensures that the final API meets regulatory standards for safety and efficacy.

• Used in the construction of the indazole core structure.
• Facilitates efficient coupling reactions in multi-step synthesis.
• Supports scalable manufacturing processes for oncology drugs.

Packaging and Storage

To maintain integrity during transit and storage, this product is packaged in durable 25 kg drums. Custom packaging solutions are available upon request to accommodate specific logistical requirements or smaller scale research needs. Proper storage conditions are essential to preserve the chemical stability of the hydrochloride salt.

We recommend storing the material in a cool, ventilated area away from direct sunlight and moisture. Containers should remain tightly sealed when not in use to prevent hygroscopic uptake. Adhering to these guidelines ensures the product remains within specification until it is ready for use in your synthesis workflow.

Commitment to Compliance

Our production facilities operate under strict quality management systems. We provide a Certificate of Analysis (COA) with every shipment, detailing the specific test results for that batch. As a responsible manufacturer, we adhere to all relevant intellectual property regulations and do not supply patented products to regions where such supply would infringe on valid patents. Partner with us for reliable supply, technical support, and competitive bulk pricing for your pharmaceutical development needs.