Intermediates

2,4-Dichloro-5-fluorobenzoyl Chloride

  • CAS No.86393-34-2
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2,4-Dichloro-5-fluorobenzoyl chloride (CAS 86393-34-2) for pharmaceutical synthesis. Reliable supply with COA.

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Product Technical Details

Product Overview

2,4-Dichloro-5-fluorobenzoyl Chloride is a highly specialized fluorinated organic intermediate designed for advanced pharmaceutical synthesis and fine chemical manufacturing. As a reactive acyl chloride derivative, this compound serves as a critical building block in the construction of complex molecular structures, particularly within the realm of medicinal chemistry. Our facility ensures that every batch meets rigorous international standards for purity and consistency, making it an ideal choice for research and industrial scale production.

This chemical features a unique substitution pattern on the benzene ring, incorporating both chloro and fluoro groups which enhance its reactivity and stability in specific synthetic pathways. The presence of the fluorine atom often improves the metabolic stability and bioavailability of the final pharmaceutical products, making this intermediate highly valuable for developing next-generation therapeutics.

Technical Specifications

We maintain strict quality control protocols to guarantee the performance of this material in your synthesis processes. The following table outlines the key physicochemical properties and quality parameters associated with our standard production grade.

ParameterSpecification
CAS Number86393-34-2
Molecular FormulaC7H2Cl3FO
Molecular Weight227.45 g/mol
AppearanceColorless To Pale Yellow Liquid
Assay (Purity)≥98.0%
Density1.6±0.1 g/cm3
Boiling Point244.1±0.0 °C at 760 mmHg
Flash Point108.7±25.9 °C
Loss On Drying≤0.5%

Industrial Applications

The primary application of 2,4-Dichloro-5-fluorobenzoyl Chloride lies in the synthesis of pharmaceutical intermediates. It is notably utilized in the production pathway of fluoroquinolone antibiotics, serving as a key precursor for acylation reactions. Beyond antibiotics, this compound is versatile enough for use in various organic synthesis projects where introducing a halogenated benzoyl group is required.

Chemists value this reagent for its reliable reactivity profile. It functions effectively as an electrophile in nucleophilic substitution reactions, allowing for the efficient formation of amide or ester bonds. This capability is essential when constructing the core scaffolds of many active pharmaceutical ingredients (APIs). Our global manufacturing process ensures that the material is supplied with the consistency needed for scale-up from laboratory research to commercial production.

Quality Assurance And Packaging

As a trusted global manufacturer, we prioritize safety and quality in every shipment. Each drum is accompanied by a comprehensive Certificate Of Analysis (COA) that verifies the identity and purity of the contents. Our quality assurance team conducts multiple checks throughout the manufacturing process to minimize impurities and ensure compliance with specified standards.

Standard packaging is available in 25kg drums, designed to protect the moisture-sensitive contents during transit. However, we understand that different projects have varying requirements. Therefore, we offer flexible packaging solutions that can be designed according to specific customer requirements. Proper storage is essential to maintain product integrity. We recommend storing the material in a cool, dry, and well-ventilated place, keeping the container tightly closed to prevent hydrolysis due to moisture exposure.