2',4'-Difluoroacetophenone
- CAS No.364-83-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
A high-purity fluorinated aromatic ketone intermediate designed for complex organic synthesis and pharmaceutical building block applications.
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Product Overview
2',4'-Difluoroacetophenone is a premier fluorinated aromatic ketone that serves as a critical building block in modern organic chemistry. Characterized by its distinct difluoro substitution pattern on the phenyl ring, this compound offers enhanced reactivity and stability profiles essential for advanced synthetic pathways. Our manufacturing facility produces this intermediate under strict quality control standards to ensure consistency across large-scale industrial batches.
The introduction of fluorine atoms into organic molecules often significantly alters biological activity and metabolic stability. As such, this ketone derivative is highly valued in the development of complex molecular structures. We specialize in providing high-purity grades suitable for demanding synthesis routes where impurity profiles must be tightly controlled.
Technical Specifications
Our production process utilizes advanced purification techniques to achieve superior assay levels. The physical properties are consistent with established chemical data, ensuring reliable performance in downstream reactions. Below are the key technical parameters for our standard grade material.
| Parameter | Specification |
|---|---|
| Chemical Name | 2',4'-Difluoroacetophenone |
| CAS Number | 364-83-0 |
| Molecular Formula | C8H6F2O |
| Molecular Weight | 156.13 g/mol |
| Appearance | Colorless to yellow clear liquid |
| Assay (Purity) | ≥98.5% |
| Moisture Content | ≤0.2% |
| Density | 1.234 g/cm3 |
| Boiling Point | 80-81 °C |
| Refractive Index | 1.488 |
Quality Assurance
Quality is the cornerstone of our chemical manufacturing operations. Every batch of 2',4'-Difluoroacetophenone undergoes rigorous testing using high-performance liquid chromatography (HPLC) and gas chromatography (GC) methods. We provide a comprehensive Certificate of Analysis (COA) with every shipment, detailing the exact composition and impurity profile.
- Strict adherence to ISO quality management systems.
- Batch traceability from raw materials to finished goods.
- Regular equipment calibration and maintenance.
- Stability testing to ensure shelf-life integrity.
Industrial Applications
This fluorinated ketone is primarily utilized as a versatile intermediate in the synthesis of heterocyclic compounds. It acts as a key precursor in the construction of pharmacologically active scaffolds and agrochemical agents. The specific positioning of the fluorine atoms allows for selective functionalization, making it indispensable for medicinal chemistry research and process development.
Common uses include the synthesis of quinolone derivatives, antifungal agents, and various kinase inhibitors. Researchers value this reagent for its solubility characteristics and reaction kinetics in nucleophilic substitution and condensation reactions. Our global supply chain ensures that laboratories and production facilities receive materials promptly to maintain project timelines.
Storage and Handling
To maintain optimal quality, 2',4'-Difluoroacetophenone should be stored in a cool, ventilated area away from direct sunlight and heat sources. Containers must be kept tightly sealed when not in use to prevent moisture absorption and oxidation. Standard safety protocols for handling organic ketones apply, including the use of appropriate personal protective equipment (PPE) such as gloves and safety goggles.
We offer flexible packaging options, including standard 200 kg drums, to accommodate various logistical requirements. For specific packaging needs or bulk orders, our sales team is available to discuss customized solutions that align with your operational constraints and safety regulations.
