2,4-Difluorophenylboronic Acid
- CAS No.144025-03-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2,4-Difluorophenylboronic Acid designed for efficient Suzuki coupling reactions and pharmaceutical intermediate synthesis.
Request Bulk PricingProduct Technical Details
Product Overview
2,4-Difluorophenylboronic Acid is a highly specialized organoboron compound that serves as a vital building block in modern organic synthesis. As a key intermediate, this chemical facilitates the construction of complex molecular architectures through palladium-catalyzed cross-coupling reactions. Our manufacturing process ensures exceptional stability and reactivity, making it an ideal choice for research and industrial-scale production environments.
The presence of fluorine atoms at the 2 and 4 positions of the phenyl ring significantly enhances the electronic properties of the molecule. This substitution pattern is particularly valuable in medicinal chemistry, where fluorine incorporation often improves metabolic stability and bioavailability of the final therapeutic agents. We supply this material with rigorous quality control standards to meet the demanding requirements of global pharmaceutical and agrochemical sectors.
Key Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 144025-03-6 |
| Molecular Formula | C6H5BF2O2 |
| Molecular Weight | 157.91 g/mol |
| Appearance | Off-white to yellow powder |
| Assay (Purity) | ≥98.0% |
| Water Content | ≤0.50% |
| Melting Point | 247-250 °C |
| Density | 1.35 g/cm3 |
Industrial Applications
This boronic acid derivative is predominantly utilized in Suzuki-Miyaura coupling reactions, which are fundamental processes for forming carbon-carbon bonds. It acts as a nucleophilic partner that couples with aryl or vinyl halides under mild conditions. The high purity level ensures minimal side reactions, leading to higher yields and easier downstream purification processes.
Beyond standard coupling, this compound finds extensive use in the synthesis of advanced pharmaceutical intermediates. It is frequently employed in the development of non-steroidal anti-inflammatory drugs and other therapeutic categories where fluorinated aromatic systems are required. The chemical's robustness allows it to withstand various reaction conditions, providing chemists with flexibility in route design.
Quality Advantages
- Consistent batch-to-batch reproducibility for reliable manufacturing.
- Low residual solvent content ensuring safety in sensitive applications.
- Optimized particle size for improved solubility and reaction kinetics.
- Comprehensive quality documentation including COA and MSDS.
- Stable shelf life when stored under recommended conditions.
Storage and Handling
To maintain optimal quality, 2,4-Difluorophenylboronic Acid should be stored in a cool, dry, and well-ventilated area. Containers must remain tightly closed to prevent moisture absorption, which can lead to hydrolysis. The material is classified under transport hazard class 8, requiring appropriate handling procedures during shipping. We recommend using personal protective equipment, including gloves and eye protection, when handling this substance in a laboratory or production setting.
Our facility adheres to strict international safety standards, ensuring that every drum shipped meets regulatory compliance for global transport. For bulk requirements, we offer flexible packaging solutions tailored to specific logistical needs, ensuring your supply chain remains uninterrupted.
