Intermediates

2,4-Dimethylbromobenzene

  • CAS No.583-70-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2,4-Dimethylbromobenzene (CAS 583-70-0), a versatile aryl bromide intermediate for advanced organic synthesis and pharmaceutical manufacturing.

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Product Technical Details

Product Overview

2,4-Dimethylbromobenzene (CAS 583-70-0) is a high-purity aryl halide widely employed as a key building block in complex organic synthesis. This compound, also known as 1-bromo-2,4-dimethylbenzene or 4-bromo-1,3-dimethylbenzene, features a bromine atom strategically positioned on a dimethyl-substituted benzene ring, enabling selective cross-coupling reactions such as Suzuki, Stille, and Negishi protocols. Its structural profile makes it particularly valuable in the construction of biaryl motifs found in active pharmaceutical ingredients, agrochemicals, and specialty materials.

Specifications

Molecular FormulaC8H9Br
Molecular Weight185.061 g/mol
AppearanceColorless to light yellow liquid
Assay≥98.0%
Density1.3 ± 0.1 g/cm³
Boiling Point207.2 ± 9.0 °C at 760 mmHg
Melting Point-1 °C
Flash Point81.6 ± 13.1 °C
Vapor Pressure0.3 ± 0.4 mmHg at 25 °C
Refractive Index1.544

Industrial Applications

As a critical intermediate in fine chemical manufacturing, 2,4-dimethylbromobenzene serves multiple roles across R&D and industrial-scale production:

  • Enables palladium-catalyzed C–C bond formation in the synthesis of complex aromatic scaffolds.
  • Acts as a precursor for functionalized heterocycles used in medicinal chemistry programs.
  • Supports the development of novel ligands, OLED materials, and liquid crystal compounds.
  • Fits seamlessly into multi-step synthetic routes requiring regioselective functionalization.

Our product is manufactured under stringent quality control systems, ensuring consistent batch-to-batch performance and compliance with international regulatory standards. Packaging is available in standard 200 kg drums or customized configurations upon request. Store in a cool, well-ventilated area away from heat sources and oxidizing agents.