Intermediates

2,5-Difluorobenzoic acid

  • CAS No.2991-28-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2,5-Difluorobenzoic acid (CAS 2991-28-8) supplied for advanced organic synthesis. Ideal building block for pharmaceutical and agrochemical manufacturing processes.

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Product Technical Details

Product Overview

2,5-Difluorobenzoic acid represents a critical fluorinated building block within the realm of advanced organic synthesis. As a specialized aromatic carboxylic acid derivative, this compound is extensively utilized by pharmaceutical and agrochemical manufacturers seeking to introduce fluorine atoms into complex molecular structures. The presence of fluorine substituents at the 2 and 5 positions significantly alters the electronic properties and metabolic stability of downstream products, making this intermediate highly valuable in modern medicinal chemistry programs.

Our manufacturing process ensures consistent quality and high purity levels, adhering to strict international standards. We understand that reliability in the supply chain is paramount for large-scale production runs. Therefore, every batch undergoes rigorous analytical testing using high-performance liquid chromatography to verify purity specifications. This commitment to quality assurance minimizes risks associated with impurities during subsequent synthetic steps.

Technical Specifications

The physical characteristics of this material facilitate easy handling and integration into various reaction schemes. Typically supplied as an off-white crystalline powder, it exhibits favorable solubility profiles in common organic solvents. The thermal stability, indicated by its melting point range, allows for versatile processing conditions without significant degradation. Please refer to the table below for detailed parameter data.

ParameterValue
CAS Number2991-28-8
Molecular FormulaC7H4F2O2
Molecular Weight158.10 g/mol
AppearanceOff-white powder
Purity (HPLC)≥99.0%
Melting Point132-134°C
Boiling Point244.7°C
Density1.432 g/cm³

Industrial Applications

Applications extend beyond traditional drug discovery into the development of novel agrochemicals and functional materials. Researchers utilize this intermediate to synthesize biologically active compounds where enhanced lipophilicity and binding affinity are required. The robust supply chain supports both pilot-scale experiments and commercial manufacturing volumes. In the context of process chemistry, the selection of high-quality starting materials directly impacts the overall yield and efficiency of the synthesis route.

2,5-Difluorobenzoic acid serves as a versatile precursor for coupling reactions, esterifications, and amide formations. Its reactivity profile is well-documented, allowing chemists to predict outcomes with greater confidence during method development. Furthermore, the economic viability of using this intermediate is supported by our scalable production capabilities.

Storage and Handling

Proper storage conditions are essential to maintain product integrity over time. We recommend keeping the material in a cool, well-ventilated environment away from direct sunlight and moisture. Packaging options are flexible to meet specific logistical requirements, ensuring safe transport to global destinations. Standard packing includes 25 kg drums, but custom configurations are available upon request.

Environmental responsibility is also a core component of our manufacturing ethos. We strive to implement green chemistry principles wherever possible, reducing waste and optimizing energy consumption during production. For clients requiring custom specifications or alternative packaging configurations, our team is equipped to handle specialized requests. Trust in our expertise to provide a reliable source of this essential fluorinated intermediate for your next project.