Intermediates

2,6-Dibromo-4-(trifluoromethoxy)aniline

  • CAS No.88149-49-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity fluorinated aniline intermediate designed for advanced organic synthesis and pharmaceutical manufacturing processes.

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Product Technical Details

Product Overview

2,6-Dibromo-4-(trifluoromethoxy)aniline is a specialized fluorinated aromatic compound that serves as a critical building block in modern organic synthesis. This highly functionalized aniline derivative features a unique substitution pattern with bromine atoms at the ortho positions and a trifluoromethoxy group at the para position. Such structural characteristics make it an invaluable precursor for the development of complex pharmaceutical agents, agrochemicals, and advanced materials. Our facility produces this compound under strict quality control protocols to ensure consistent performance in downstream reactions.

The presence of the trifluoromethoxy moiety enhances the lipophilicity and metabolic stability of final products, while the dibromo substitution allows for versatile cross-coupling reactions. Researchers and process chemists rely on this intermediate for constructing biaryl systems and heterocyclic frameworks essential in drug discovery pipelines. We are committed to supplying this material with high chemical purity to support efficient synthesis routes.

Key Physical And Chemical Properties

Understanding the physicochemical profile of this intermediate is vital for safe handling and process optimization. The following table outlines the standard specifications verified through our analytical laboratories. Each batch is tested to confirm compliance with these parameters before release.

ParameterSpecification
Chemical Name2,6-Dibromo-4-(trifluoromethoxy)aniline
CAS Number88149-49-9
Molecular FormulaC7H4Br2F3NO
Molecular Weight334.916 g/mol
AppearanceOff-white crystalline powder
Assay≥98.0%
Melting Point70-74 °C
Boiling Point253.8±35.0 °C at 760 mmHg
Density2.0±0.1 g/cm3
Flash Point107.3±25.9 °C

Industrial Applications

This fluorinated aniline derivative is primarily utilized as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). The electron-withdrawing nature of the trifluoromethoxy group combined with the reactive bromine sites enables diverse chemical transformations. Common applications include palladium-catalyzed coupling reactions such as Suzuki, Heck, and Buchwald-Hartwig aminations. These processes are fundamental in creating novel therapeutic compounds targeting various disease states.

Beyond pharmaceuticals, this compound finds utility in agrochemical research where fluorinated structures are prized for their enhanced biological activity and environmental stability. Material science researchers also explore its potential in developing organic electronic components due to its specific electronic properties. Our global clientele trusts our material for maintaining reproducibility in their R&D and production scales.

Quality Assurance And Storage

We maintain a robust quality management system to guarantee the integrity of every shipment. Each drum is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. Our manufacturing process adheres to international safety and environmental standards, ensuring that the product is free from unauthorized contaminants. Customers can request custom packaging solutions to meet their specific logistical requirements.

For optimal stability, store this product in a cool, ventilated area away from direct sunlight and moisture. Keep containers tightly closed when not in use to prevent degradation. Proper handling procedures should be followed according to standard laboratory safety guidelines. We offer global shipping capabilities with secure packaging to ensure the product arrives in perfect condition. Contact our sales team for detailed technical data sheets and bulk pricing inquiries.