2,6-Dichloro-3-fluoropyridine
- CAS No.52208-50-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 2,6-Dichloro-3-fluoropyridine (CAS 52208-50-1) designed for advanced organic synthesis and pharmaceutical intermediate applications.
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Product Overview
2,6-Dichloro-3-fluoropyridine is a highly valued heterocyclic compound widely utilized in the field of medicinal chemistry and agrochemical development. As a fluorinated pyridine derivative, this substance serves as a critical building block for constructing complex molecular architectures. The presence of both chlorine and fluorine substituents on the pyridine ring offers unique reactivity profiles, enabling chemists to perform selective nucleophilic substitutions and cross-coupling reactions with high precision.
Our manufacturing process ensures consistent quality and reliability, making this product an ideal choice for research laboratories and industrial scale production facilities. The strategic placement of halogen atoms facilitates diverse synthetic pathways, particularly in the development of kinase inhibitors and other therapeutic agents where metabolic stability is paramount.
Key Physical and Chemical Properties
| Parameter | Value |
|---|---|
| Chemical Name | 2,6-Dichloro-3-fluoropyridine |
| CAS Number | 52208-50-1 |
| Molecular Formula | C5H2Cl2FN |
| Molecular Weight | 165.980 g/mol |
| Appearance | Off-white crystalline powder |
| Assay | ≥98.0% |
| Melting Point | 44-46 °C |
| Boiling Point | 196.0±35.0 °C at 760 mmHg |
| Density | 1.5±0.1 g/cm3 |
| Flash Point | 72.4±25.9 °C |
Industrial Applications
This fluorinated pyridine intermediate is extensively employed in the synthesis of pharmaceutical active ingredients. The fluorine atom enhances lipophilicity and metabolic stability, which are crucial properties for drug candidates targeting central nervous system disorders or oncological indications. Additionally, it serves as a versatile precursor in the agrochemical sector for producing herbicides and fungicides with improved environmental profiles.
Key advantages for process chemists include:
- High reactivity towards nucleophilic aromatic substitution.
- Excellent compatibility with palladium-catalyzed coupling reactions.
- Superior stability under standard storage conditions.
- Facilitates the introduction of fluorine motifs into lead compounds.
Quality Assurance and Packaging
We adhere to strict quality control protocols to ensure every batch meets the specified purity standards of ≥98.0%. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing test results for identity, purity, and physical constants. Our facility employs advanced analytical techniques such as HPLC and NMR to verify product integrity.
Standard packaging consists of 25 kg drums, designed to protect the material from moisture and light exposure. We also offer custom packaging solutions to meet specific logistical requirements. Storage recommendations include keeping the container in a cool, ventilated place away from incompatible substances. Our global supply chain ensures timely delivery to support your production schedules without interruption.
