Intermediates

2,6-Difluoro-3-nitrobenzonitrile

  • CAS No.143879-77-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2,6-Difluoro-3-nitrobenzonitrile (CAS 143879-77-0) designed for advanced organic synthesis. Reliable supply with ≥98.0% assay for pharmaceutical and agrochemical manufacturing.

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Product Technical Details

Product Overview

2,6-Difluoro-3-nitrobenzonitrile represents a critical fluorinated building block within the realm of advanced organic synthesis. As a specialized intermediate, this compound is engineered to meet the rigorous demands of modern pharmaceutical and agrochemical manufacturing processes. The incorporation of fluorine atoms into aromatic structures significantly enhances the metabolic stability and bioavailability of downstream active ingredients. Our facility produces this material using state-of-the-art fluorination technologies, ensuring consistent batch-to-batch quality and high chemical integrity. We understand that precision in molecular structure is paramount for successful reaction pathways, which is why our production protocols adhere to strict international quality management systems. Supply chain reliability is a key focus, ensuring that global partners receive their orders on time without compromising on specification standards.

This light yellow powder is characterized by its distinct physical properties, including a defined melting point and specific density, making it suitable for various substitution reactions. The presence of both nitro and cyano functional groups on the fluorinated benzene ring offers versatile reactivity for chemists designing complex molecular architectures. Whether utilized in the synthesis of quinolone antibiotics or novel herbicide formulations, this intermediate serves as a reliable foundation for high-value chemical production.

Technical Specifications

Quality control is the cornerstone of our manufacturing operation. Each batch of 2,6-Difluoro-3-nitrobenzonitrile undergoes comprehensive analytical testing to verify compliance with specified parameters. We employ high-performance liquid chromatography (HPLC) and gas chromatography (GC) methods to ascertain purity levels. The following table outlines the key physical and chemical characteristics typically associated with this product grade.

ParameterValue
CAS Number143879-77-0
Molecular FormulaC7H2F2N2O2
Molecular Weight184.100 g/mol
AppearanceLight yellow powder
Assay≥98.0%
Melting Point50 °C
Boiling Point263.7 °C
Density1.5 g/cm3

Industrial Applications

The primary utility of this fluorinated nitrile lies in its role as a precursor for complex organic molecules. In the pharmaceutical sector, it is frequently employed in the construction of heterocyclic compounds found in therapeutic agents. The electron-withdrawing nature of the nitro and cyano groups facilitates nucleophilic aromatic substitution, allowing for the precise introduction of other functional groups. Agrochemical developers also value this intermediate for creating robust crop protection agents that require high environmental stability.

  • Pharmaceutical intermediate synthesis for antibiotic and antiviral drugs.
  • Agrochemical formulation development for herbicides and pesticides.
  • Material science research involving fluorinated polymers.
  • Custom organic synthesis projects requiring high-purity building blocks.

Quality Assurance and Packaging

We are committed to delivering products that exceed industry standards. Our quality assurance team conducts random sampling and retention testing to ensure long-term stability. In addition to internal testing, we welcome third-party audits and verification processes. Our regulatory compliance team ensures that all documentation meets the requirements for international trade, including proper classification and safety data sheet generation. This dedication to transparency builds long-term trust with our clientele across the pharmaceutical and chemical industries. The material is packaged in secure 25 kg drums, designed to protect the contents from moisture and physical damage during transit. Custom packaging solutions are available upon request to accommodate specific logistical requirements. Every shipment is accompanied by a Certificate of Analysis (COA) detailing the specific test results for that batch.

Storage and Handling

To maintain optimal chemical stability, 2,6-Difluoro-3-nitrobenzonitrile should be stored in a cool, ventilated environment away from direct sunlight and heat sources. Containers must be kept tightly closed when not in use to prevent exposure to atmospheric moisture. Personnel handling this material should adhere to standard safety protocols, including the use of appropriate personal protective equipment (PPE) such as gloves and safety goggles. Proper ventilation is essential during weighing and transfer operations to minimize inhalation risks. We recommend consulting the safety data sheet for comprehensive handling instructions before beginning any laboratory or industrial work.