2,6-Difluoro-4-hydroxybenzonitrile
- CAS No.123843-57-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2,6-Difluoro-4-hydroxybenzonitrile intermediate for pharmaceutical and agrochemical organic synthesis applications.
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Product Overview
2,6-Difluoro-4-hydroxybenzonitrile represents a critical fluorinated aromatic compound designed for advanced organic synthesis applications within the pharmaceutical and agrochemical sectors. As a specialized building block, this molecule facilitates the construction of complex molecular architectures required for modern therapeutic agents. The strategic placement of fluorine atoms at the 2 and 6 positions significantly enhances metabolic stability and bioavailability in downstream drug products. Our manufacturing facility produces this intermediate under strict quality control protocols to ensure it meets the rigorous demands of sensitive reaction pathways used in medicinal chemistry.
Key Quality Advantages
- Exceptional chemical purity levels minimizing downstream purification requirements.
- Stable physical properties ensuring safe long-term storage and handling.
- Versatile reactivity profile suitable for diverse synthetic routes and transformations.
- Comprehensive quality documentation including Certificates of Analysis for every batch.
- Consistent supply chain reliability supporting large-scale production needs.
Technical Specifications
The following table outlines the critical physical and chemical parameters verified through our accredited quality control laboratories. Each production batch undergoes rigorous testing using advanced analytical techniques such as HPLC and NMR to confirm identity and purity. We adhere to international standards to guarantee performance consistency across all shipments.
| Parameter | Specification |
|---|---|
| Chemical Name | 2,6-Difluoro-4-hydroxybenzonitrile |
| CAS Number | 123843-57-2 |
| Molecular Formula | C7H3F2NO |
| Molecular Weight | 155.102 g/mol |
| Appearance | White to off-white crystalline powder |
| Assay (Purity) | ≥98.0% |
| Melting Point | 127 °C |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 279.8±40.0 °C at 760 mmHg |
Industrial Applications
This intermediate is predominantly utilized in the synthesis of kinase inhibitors and other targeted therapeutic agents where fluorination is key to efficacy. It also finds significant application in developing high-performance agrochemicals where fluorine substitution improves environmental resilience and biological activity. Researchers and process chemists value this compound for its reliable performance in nucleophilic substitution reactions and cross-coupling processes. The nitrile functional group offers further versatility for conversion into amines, acids, or tetrazoles depending on the specific synthetic requirements of the final active pharmaceutical ingredient.
Storage and Handling
To maintain optimal quality, store this material in a cool, ventilated environment away from direct sunlight and heat sources. Keep containers tightly sealed when not in use to prevent moisture absorption which could affect reactivity. Handle with appropriate personal protective equipment including gloves and safety glasses during weighing and transfer operations. We offer flexible packaging options including 25 kg drums or custom configurations based on specific customer logistics requirements. Global shipping is available with full regulatory compliance documentation to ensure smooth customs clearance.
