2,6-Difluorotoluene
- CAS No.443-84-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
2,6-Difluorotoluene is a high-purity fluorinated aromatic intermediate essential for advanced organic synthesis and pharmaceutical manufacturing processes.
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Product Overview
2,6-Difluorotoluene, also known chemically as 1,3-Difluoro-2-methylbenzene, represents a critical fluorinated aromatic building block within the modern chemical industry. As a specialized intermediate, this compound is highly valued for its unique substitution pattern, which offers distinct reactivity profiles essential for complex molecular construction. Our facility produces this material under strict quality control standards to ensure consistency across batches, making it an ideal choice for research and development teams as well as large-scale industrial production lines.
The presence of fluorine atoms at the 2 and 6 positions significantly influences the electronic and steric properties of the benzene ring. This specific configuration enhances metabolic stability and lipophilicity in downstream pharmaceutical candidates, making it a preferred choice for medicinal chemists designing novel therapeutic agents. Furthermore, its volatility and solubility characteristics facilitate efficient processing in various synthetic routes.
Key Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 443-84-5 |
| Molecular Formula | C7H6F2 |
| Molecular Weight | 128.119 g/mol |
| Appearance | Colorless transparent liquid |
| Purity (Assay) | ≥98.0% |
| Boiling Point | 113.9±20.0 °C at 760 mmHg |
| Density | 1.1±0.1 g/cm3 |
| Refractive Index | 1.457 |
| Flash Point | 10.0±0.0 °C |
Industrial Applications
This fluorinated intermediate serves as a foundational component in the synthesis of agrochemicals, pharmaceuticals, and advanced functional materials. In the pharmaceutical sector, it is frequently utilized to introduce fluorine motifs into drug molecules, a strategy known to improve bioavailability and binding affinity. The compound acts as a versatile precursor for cross-coupling reactions, nucleophilic substitutions, and lithiation processes.
Beyond medicine, 2,6-Difluorotoluene finds application in the development of liquid crystals and polymer additives. Its chemical stability allows it to withstand harsh reaction conditions, ensuring high yields in multi-step synthesis pathways. Manufacturers rely on this material to create high-performance compounds that meet rigorous industry standards for purity and performance.
Quality Assurance and Packaging
We understand that consistency is paramount in chemical manufacturing. Every batch of 2,6-Difluorotoluene undergoes comprehensive analytical testing using Gas Chromatography (GC) and other advanced techniques to verify purity levels and identify any potential impurities. A Certificate of Analysis (COA) is provided with every shipment to document compliance with specified parameters.
Standard packaging consists of 200 kg drums, designed to maintain integrity during transit. However, we offer flexible packaging solutions tailored to specific customer requirements, ensuring safe delivery regardless of order size. Our logistics network supports global shipping, adhering to all international hazardous material regulations.
Storage and Handling
To maintain optimal quality, this product should be stored in a cool, ventilated area away from direct sunlight and heat sources. Containers must remain tightly sealed when not in use to prevent moisture absorption or contamination. Personnel handling this chemical should follow standard safety protocols, including the use of appropriate personal protective equipment (PPE) such as gloves and safety goggles. In case of spills, standard chemical containment procedures should be implemented immediately to ensure workplace safety.
