Intermediates

2-Bromo-3-chloro-5-methylpyridine

  • CAS No.65550-81-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 2-Bromo-3-chloro-5-methylpyridine intermediate for advanced organic synthesis and pharmaceutical manufacturing.

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Product Technical Details

Product Overview

2-Bromo-3-chloro-5-methylpyridine is a highly specialized halogenated heterocyclic compound that serves as a critical building block in modern organic chemistry. As a derivative of the pyridine ring system, this molecule features distinct reactive sites at the bromo and chloro positions, enabling versatile functionalization through cross-coupling reactions. Our facility produces this intermediate under strict quality control standards to ensure consistency for downstream pharmaceutical and agrochemical applications.

The presence of both bromine and chlorine substituents on the methylated pyridine core provides chemists with orthogonal reactivity options. This allows for selective transformations during multi-step synthesis routes, making it an invaluable asset for medicinal chemistry teams developing novel active pharmaceutical ingredients (APIs). We prioritize industrial purity levels to minimize impurities that could affect catalytic efficiency in subsequent reaction steps.

Technical Specifications

ParameterValue
Chemical Name2-Bromo-3-chloro-5-methylpyridine
CAS Number65550-81-4
Molecular FormulaC6H5BrClN
Molecular Weight206.468 g/mol
AppearanceLight yellow crystalline powder
Assay (Purity)≥98.0%
Density1.6±0.1 g/cm3
Boiling Point254.5±35.0 °C at 760 mmHg
Flash Point107.7±25.9 °C
Refractive Index1.571

Industrial Applications

This compound is primarily utilized as a key intermediate in the synthesis of complex organic molecules. In the pharmaceutical sector, it is frequently employed in the construction of kinase inhibitors and other heterocyclic drug candidates. The halogen atoms facilitate palladium-catalyzed coupling reactions such as Suzuki-Miyaura or Buchwald-Hartwig aminations, which are fundamental processes in modern drug discovery.

Beyond pharmaceuticals, this pyridine derivative finds application in agricultural chemistry for the development of novel pesticides and herbicides. Research laboratories also procure this material for method development and structural activity relationship (SAR) studies. Our manufacturing process ensures that the batch-to-batch variability is minimized, supporting reliable scale-up from laboratory research to commercial production.

Quality Assurance and Packaging

Quality is paramount in the production of fine chemical intermediates. Each batch of 2-Bromo-3-chloro-5-methylpyridine undergoes rigorous analytical testing using High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy. We provide a comprehensive Certificate of Analysis (COA) with every shipment to verify compliance with specified purity standards.

For logistics, the product is packaged in 25 kg drums lined with moisture-proof materials to maintain stability during transit. Custom packaging solutions are available upon request to meet specific supply chain requirements. Storage recommendations include keeping the containers in a cool, ventilated area away from direct sunlight and incompatible substances. As a global manufacturer, we support international shipping with all necessary documentation, including MSDS, to ensure smooth customs clearance and safe handling.