Intermediates

2-Bromo-3-fluoro-5-methylpyridine

  • CAS No.34552-16-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Bromo-3-fluoro-5-methylpyridine (CAS 34552-16-4) designed for advanced organic synthesis. Reliable supply for pharmaceutical intermediate manufacturing with strict quality control.

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Product Technical Details

Product Overview

2-Bromo-3-fluoro-5-methylpyridine is a sophisticated halogenated heterocyclic compound that serves as a vital building block in modern organic synthesis. Characterized by its unique substitution pattern on the pyridine ring, this chemical entity offers exceptional reactivity for cross-coupling reactions and nucleophilic substitutions. Our manufacturing facility produces this intermediate under stringent quality management systems to ensure consistency and reliability for downstream pharmaceutical and agrochemical applications.

The presence of both bromine and fluorine substituents provides chemists with versatile handles for further functionalization. This dual-halogen structure allows for selective reaction pathways, making it an indispensable tool in the development of complex molecular architectures. We prioritize industrial purity standards to minimize impurities that could affect subsequent reaction yields or complicate purification processes.

Technical Specifications

Parameter Specification
Chemical Name 2-Bromo-3-fluoro-5-methylpyridine
CAS Number 34552-16-4
Molecular Formula C6H5BrFN
Molecular Weight 190.01 g/mol
Appearance White Crystalline Powder
Purity ≥99.0%
Boiling Point 205.0±35.0 °C at 760 mmHg
Density 1.6±0.1 g/cm3
Flash Point 77.8±25.9 °C
Refractive Index 1.530

Industrial Applications

This compound is primarily utilized as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and advanced agrochemicals. Its structural properties make it particularly suitable for palladium-catalyzed coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig aminations. Researchers leverage this building block to introduce specific heterocyclic motifs into larger drug candidates, enhancing biological activity and metabolic stability.

Beyond pharmaceuticals, this fluorinated pyridine derivative finds application in materials science and fine chemical production. The high purity grade we supply ensures compatibility with sensitive catalytic systems, reducing the risk of catalyst poisoning. Our global clientele relies on this product for scaling up synthesis routes from laboratory discovery to commercial manufacturing.

Quality Assurance and Storage

Quality is paramount in our production process. Every batch of 2-Bromo-3-fluoro-5-methylpyridine undergoes rigorous analytical testing, including HPLC, GC-MS, and NMR spectroscopy, to verify identity and purity. We provide a comprehensive Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our facility adheres to international safety and environmental standards to ensure sustainable manufacturing practices.

For optimal stability, the product should be stored in a tightly closed container within a cool, dry, and well-ventilated area. Protection from moisture and direct sunlight is recommended to maintain chemical integrity over extended periods. We offer flexible packaging options, including 25 kg drums, to accommodate various production scales while ensuring safe transportation globally.