Intermediates

2-Bromo-3-Fluoroaniline

  • CAS No.111721-75-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Bromo-3-Fluoroaniline liquid for pharmaceutical synthesis. Reliable global supply with COA.

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Product Technical Details

Product Overview

2-Bromo-3-Fluoroaniline is a specialized fluorinated aromatic amine designed for advanced organic synthesis within the pharmaceutical industry. As a critical building block, this compound combines the reactivity of a bromo substituent with the metabolic stability benefits of fluorine incorporation. Our manufacturing process ensures consistent quality, making it an ideal choice for medicinal chemists developing novel therapeutic agents. The presence of both halogen and amine functional groups allows for versatile chemical transformations, supporting complex molecule construction.

Key Specifications

ParameterValue
Chemical Name2-Bromo-3-Fluoroaniline
CAS Number111721-75-6
Molecular FormulaC6H5BrFN
Molecular Weight190.01 g/mol
Purity≥98.0%
AppearanceLiquid
Boiling Point301.6°C at 760mmHg
Density2.074 g/cm3
Flash Point136.2°C

Industrial Applications

This fluorinated aniline derivative serves as a pivotal intermediate in the synthesis of active pharmaceutical ingredients (APIs). The bromo group facilitates palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig aminations, enabling the formation of carbon-carbon and carbon-nitrogen bonds. Meanwhile, the fluorine atom acts as a bioisostere, often improving the lipophilicity and metabolic stability of the final drug candidate. It is extensively used in the research and development of neurological therapeutics, oncology treatments, and other complex organic structures requiring precise substitution patterns.

Quality Assurance and Storage

We adhere to strict quality control protocols to guarantee the integrity of every batch. Each shipment is accompanied by a Certificate of Analysis (COA) verifying purity and physical constants. To maintain stability, the product should be stored in a tightly closed container within a cool, dry, and well-ventilated area. It is essential to keep the material away from incompatible substances such as strong oxidizing agents. Our packaging options include 25kg drums, ensuring safe transport for bulk industrial requirements. We commit to providing reliable supply chains for global manufacturers seeking high-performance chemical intermediates.