2-Bromo-3-fluoropyridine
- CAS No.40273-45-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 2-Bromo-3-fluoropyridine for pharmaceutical synthesis. Reliable supply with COA.
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Product Overview
2-Bromo-3-fluoropyridine is a highly specialized halogenated heterocyclic compound that serves as a critical building block in modern medicinal chemistry and organic synthesis. As a key pharmaceutical intermediate, this compound features a pyridine ring substituted with both bromine and fluorine atoms at the second and third positions respectively. This specific substitution pattern provides unique reactivity profiles that are essential for constructing complex molecular architectures found in advanced therapeutic agents.
Our manufacturing facility ensures that every batch of 2-Bromo-3-fluoropyridine meets rigorous international quality standards. We understand the precision required in pharmaceutical development, which is why our production processes are designed to maintain consistent purity levels and minimize impurities that could affect downstream reactions. This chemical is particularly valued for its stability and versatility in cross-coupling reactions, nucleophilic substitutions, and various catalytic processes.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 2-Bromo-3-fluoropyridine |
| CAS Number | 40273-45-8 |
| Molecular Formula | C5H3BrFN |
| Molecular Weight | 175.99 g/mol |
| Appearance | Yellow liquid |
| Purity | ≥98.0% |
| Density | 1.7 ± 0.1 g/cm3 |
| Boiling Point | 173.2 ± 20.0 °C at 760 mmHg |
| Flash Point | 58.6 ± 21.8 °C |
| Refractive Index | 1.534 |
Chemical Properties and Reactivity
The presence of the bromine atom at the 2-position makes this compound an excellent substrate for palladium-catalyzed cross-coupling reactions such as Suzuki, Heck, and Sonogashira couplings. Meanwhile, the fluorine atom at the 3-position influences the electronic properties of the pyridine ring, enhancing metabolic stability in final drug candidates. This dual functionality allows chemists to selectively functionalize the molecule at different sites, providing significant flexibility in synthetic route design.
Handling this substance requires adherence to standard laboratory safety protocols. It should be stored in a tightly closed container within a cool, dry environment to prevent degradation or moisture absorption. Proper ventilation is recommended during use to avoid inhalation of vapors. Our quality control team performs comprehensive testing on each production lot to verify physical constants and chemical identity, ensuring reliability for your research and manufacturing needs.
Industrial Applications
Primarily utilized in the pharmaceutical industry, 2-Bromo-3-fluoropyridine acts as a precursor for a wide range of bioactive molecules. It is frequently employed in the synthesis of kinase inhibitors, antiviral agents, and other small molecule drugs where heterocyclic motifs are required. Beyond pharmaceuticals, this intermediate finds applications in agrochemical research and materials science where functionalized pyridines are needed for polymer modification or ligand design.
- Pharmaceutical intermediate for drug discovery
- Building block for heterocyclic synthesis
- Reagent for cross-coupling reactions
- Component in agrochemical development
- Material science applications
Quality Assurance and Packaging
We are committed to delivering products that exceed industry expectations. Each drum of 2-Bromo-3-fluoropyridine is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. Standard packaging consists of 25 kg drums, though custom packaging solutions are available upon request to suit specific logistical requirements. Our global supply chain ensures timely delivery to laboratories and manufacturing sites worldwide, supported by responsive customer service and technical expertise.
