2-Bromo-3-nitro-4-picoline
- CAS No.23056-45-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
2-Bromo-3-nitro-4-picoline is a high-purity pyridine derivative used extensively in organic synthesis. Available in bulk quantities with comprehensive quality documentation.
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Product Overview
2-Bromo-3-nitro-4-picoline represents a critical halogenated heterocyclic building block within the pharmaceutical and agrochemical industries. As a substituted pyridine derivative, this compound features both bromine and nitro functional groups positioned strategically on the aromatic ring, enabling diverse chemical transformations. Our facility specializes in the production of this high-value intermediate, ensuring consistent quality for complex organic synthesis pathways.
The presence of the bromine atom facilitates cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings, while the nitro group offers potential for reduction to amines or further functionalization. This dual reactivity makes the compound an essential precursor for developing advanced medicinal chemistry candidates and specialized fine chemicals.
Technical Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 2-Bromo-3-nitro-4-picoline |
| CAS Number | 23056-45-3 |
| Molecular Formula | C6H5BrN2O2 |
| Molecular Weight | 217.020 g/mol |
| Appearance | Brown crystalline powder |
| Purity (Assay) | ≥98.0% |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 263.3±35.0 °C at 760 mmHg |
| Flash Point | 113.0±25.9 °C |
Industrial Applications
This chemical intermediate serves primarily as a key building block in the synthesis of heterocyclic compounds. Researchers and process chemists utilize this material for constructing more complex molecular architectures required in drug discovery programs. The high purity standard ensures minimal side reactions during sensitive catalytic processes.
- Utilized in nucleophilic aromatic substitution reactions.
- Employed in palladium-catalyzed cross-coupling methodologies.
- Serves as a precursor for kinase inhibitor scaffolds.
- Applicable in the synthesis of agrochemical active ingredients.
Quality Assurance and Handling
Quality control is paramount in our manufacturing process. Every batch of 2-Bromo-3-nitro-4-picoline undergoes rigorous testing using HPLC and NMR spectroscopy to verify identity and purity levels. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all critical quality attributes.
For safe handling, store the material in a cool, ventilated place away from incompatible substances. The compound should be kept in tightly closed containers to prevent moisture absorption. Our packaging options include 25 kg drums, with customization available to meet specific logistical requirements. As a global manufacturer, we ensure reliable shipping and supply chain stability for all international clients seeking premium chemical intermediates.
