Intermediates

2-Bromo-4-fluoroaniline

  • CAS No.1003-98-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 2-Bromo-4-fluoroaniline (CAS 1003-98-1) designed for pharmaceutical synthesis. Reliable supply with strict quality control.

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Product Technical Details

Product Overview

2-Bromo-4-fluoroaniline is a highly specialized aromatic amine derivative that serves as a critical building block in modern organic synthesis. Characterized by the presence of both bromine and fluorine substituents on the benzene ring, this compound offers unique reactivity profiles that are essential for the development of complex molecular structures. Our facility produces this chemical intermediate under stringent quality management systems to ensure consistency and reliability for downstream applications.

The strategic placement of halogen atoms allows for versatile coupling reactions, making it an indispensable resource for medicinal chemistry and agrochemical research. As a trusted global manufacturer, we understand the precise requirements of pharmaceutical developers and provide material that meets rigorous industry standards for purity and performance.

Technical Specifications

ParameterValue
Chemical Name2-Bromo-4-fluoroaniline
CAS Number1003-98-1
Molecular FormulaC6H5BrFN
Molecular Weight190.01 g/mol
Purity≥98.0%
AppearanceClear yellow-brown liquid
Melting Point41°C
Boiling Point221°C
Density1.67 g/cm3

Industrial Applications

This fluorinated aniline derivative is primarily utilized in the pharmaceutical industry as a key intermediate for the synthesis of active pharmaceutical ingredients (APIs). The fluorine atom often enhances metabolic stability and bioavailability in drug candidates, while the bromine group facilitates cross-coupling reactions such as Suzuki or Buchwald-Hartwig aminations. Beyond pharmaceuticals, it finds utility in the production of advanced agrochemicals and functional materials where specific electronic properties are required.

  • Essential building block for novel drug discovery programs.
  • Used in the synthesis of kinase inhibitors and receptor modulators.
  • Applicable in the development of high-performance polymers.
  • Supports research in organic electronic materials.

Quality Assurance and Handling

We maintain a comprehensive quality control protocol that includes advanced analytical testing such as HPLC, GC-MS, and NMR spectroscopy. Every batch is accompanied by a Certificate of Analysis (COA) to verify compliance with specified parameters. Proper handling is crucial due to the chemical nature of aromatic amines. We recommend storing the product in tightly closed containers within a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents.

Our packaging options are designed to ensure safety during transit, typically available in 25kg drums or customized according to client requirements. As a dedicated partner in the chemical supply chain, we commit to providing timely logistics support and technical documentation to facilitate your research and production processes efficiently.