2-Bromo-4-fluorobenzonitrile
- CAS No.36282-26-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 2-Bromo-4-fluorobenzonitrile (CAS 36282-26-5), a versatile halogenated aromatic intermediate for advanced organic synthesis in pharmaceutical and agrochemical R&D.
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Product Overview
2-Bromo-4-fluorobenzonitrile is a high-value halogenated aromatic building block widely employed in the synthesis of complex organic molecules. With its dual functional handles—the electron-withdrawing nitrile group and the reactive bromo substituent—this compound serves as a strategic intermediate in cross-coupling reactions such as Suzuki, Stille, and Buchwald-Hartwig aminations. Its regioselective substitution pattern enables precise molecular construction in medicinal chemistry and materials science.
Specifications
| Molecular Formula | C₇H₃BrFN |
|---|---|
| Molecular Weight | 200.008 g/mol |
| CAS Number | 36282-26-5 |
| Appearance | White to brown crystalline powder |
| Assay | ≥98.0% |
| Melting Point | 77–78 °C |
| Boiling Point | 262.4 ± 25.0 °C at 760 mmHg |
| Density | 1.7 ± 0.1 g/cm³ |
| Flash Point | 112.5 ± 23.2 °C |
| Vapour Pressure | 0.0 ± 0.5 mmHg at 25 °C |
| Refractive Index | 1.578 |
Industrial Applications
As a key intermediate in fine chemical manufacturing, 2-Bromo-4-fluorobenzonitrile is primarily utilized in the development of active pharmaceutical ingredients (APIs), crop protection agents, and specialty electronic materials. Its structural features allow chemists to introduce fluorine-containing motifs—known for enhancing metabolic stability and bioavailability—into target molecules. The bromine atom facilitates palladium-catalyzed transformations, making this compound indispensable in modern drug discovery pipelines.
- Ideal for constructing fluorinated heterocycles and biaryl systems
- Compatible with a wide range of transition-metal-catalyzed reactions
- Supplied in industrial-grade purity suitable for scale-up processes
Stored in a cool, well-ventilated area away from heat and incompatible materials, this product is typically packed in 25 kg drums or customized packaging upon request to meet global regulatory and logistical standards.
